卡培他滨（希罗达®）和替莫唑胺（泰道®）治疗壶腹神经内分泌肿瘤。
Treatment of ampullary neuroendocrine tumor by Capecitabine (Xeloda®) and Temozolomide (Temodal®).
作者信息
Noorali Sima, Haghighi Shirin
机构信息
Department of Hematology & Oncology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Gastroenterol Hepatol Bed Bench. 2021 Winter;14(1):85-88.
Neuroendocrine tumors of the gastrointestinal tract and pancreas include a range of rare and diverse neoplasms with unique tumor biology, natural history, and clinical management. Neuroendocrine tumors of the ampulla of Vater are extremely uncommon cancers that account for only about 0.3%-1% of all gastrointestinal neuroendocrine tumors. Approximately 139 cases have been reported to date. In this paper, we describe two patients with low to intermediate grades of ampullary neuroendocrine tumors that underwent multiple courses of chemotherapy with Capecitabine (Xeloda®) and Temozolomide (Temodal®). Our two patients had a dramatic response to this regimen. According to our study, it seems that ampullary neuroendocrine tumors have behavior like pancreatic neuroendocrine tumors which requires further studies in more patients.
胃肠道和胰腺的神经内分泌肿瘤包括一系列罕见且多样的肿瘤，具有独特的肿瘤生物学特性、自然病史和临床管理方式。壶腹神经内分泌肿瘤是极其罕见的癌症，仅占所有胃肠道神经内分泌肿瘤的约0.3%-1%。迄今为止，大约已报告139例。在本文中，我们描述了两名低至中度分级的壶腹神经内分泌肿瘤患者，他们接受了多疗程的卡培他滨（希罗达®）和替莫唑胺（泰道®）化疗。我们的两名患者对该治疗方案反应显著。根据我们的研究，壶腹神经内分泌肿瘤似乎具有与胰腺神经内分泌肿瘤相似的行为，这需要在更多患者中进行进一步研究。
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