Jiménez-Salazar Javier E, Damian-Ferrara Rebeca, Arteaga Marcela, Batina Nikola, Damián-Matsumura Pablo
Department of Biology of Reproduction, Division of Biological Sciences and Health (DCBS), Autonomous Metropolitan University (UAM), Mexico City, Mexico.
School of Medicine, National Autonomous University of Mexico (UNAM), Mexico City, Mexico.
Front Oncol. 2021 Mar 19;11:631007. doi: 10.3389/fonc.2021.631007. eCollection 2021.
Estrogens have been implicated in the etiology of breast cancer for a long time. It has been stated that long-term exposure to estrogens is associated with a higher incidence of breast cancer, since estradiol (E) stimulates breast cell growth; however, its effect on DNA damage/repair is only starting to be investigated. Recent studies have documented that estrogens are able to modify the DNA damage response (DDR) and DNA repair mechanisms. On the other hand, it has been proposed that DDR machinery can be altered by estrogen signaling pathways, that can be related to cancer progression and chemoresistance. We have demonstrated that E promotes c-Src activation and breast cancer cell motility, through a non-genomic pathway. This review discusses scientific evidence supporting this non-genomic mechanism where estrogen modifies the DNA repair pathways, and its relationship to potential causes of chemoresistance.
长期以来，雌激素一直被认为与乳腺癌的病因有关。据说长期接触雌激素与乳腺癌的较高发病率相关，因为雌二醇（E）会刺激乳腺细胞生长；然而，其对DNA损伤/修复的影响才刚刚开始被研究。最近的研究表明，雌激素能够改变DNA损伤反应（DDR）和DNA修复机制。另一方面，有人提出DDR机制可能会被雌激素信号通路改变，这可能与癌症进展和化疗耐药性有关。我们已经证明，E通过非基因组途径促进c-Src激活和乳腺癌细胞迁移。这篇综述讨论了支持这种雌激素改变DNA修复途径的非基因组机制的科学证据，以及它与化疗耐药性潜在原因的关系。
