一锅法制备（）-α,β-不饱和醛：通过 2,2-二甲氧基乙基对甲苯磺酰基砜的 Julia-Kocienski 反应，然后进行酸水解。
One-Pot Preparation of ()-α,β-Unsaturated Aldehydes by a Julia-Kocienski Reaction of 2,2-Dimethoxyethyl PT Sulfone Followed by Acid Hydrolysis.
机构信息
Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido 1-1, Gifu 501-1193, Japan.
出版信息
J Org Chem. 2021 May 7;86(9):6969-6973. doi: 10.1021/acs.joc.1c00479. Epub 2021 Apr 19.
PMID:33870683
Abstract
()-α,β-Unsaturated aldehydes were synthesized by the Julia-Kocienski reaction of 2,2-dimethoxyethyl 1-phenyl-1-tetrazol-5-yl (PT) sulfone with various aldehydes, followed by acid hydrolysis. The reaction could be carried out in one pot, and various ()-α,β-unsaturated aldehydes were obtained in a short time and with high yields.
摘要
通过 2,2-二甲氧基乙基 1-苯基-1-四唑-5-基（PT）砜与各种醛的 Julia-Kocienski 反应，随后进行酸水解，可以合成()-α,β-不饱和醛。该反应可以一锅进行，各种()-α,β-不饱和醛可以在短时间内以高产率得到。
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