University of Exeter, Exeter, UK.
Eating Disorders Service for Children and Adolescents, Elysium Healthcare, Rhodes Wood Hospital, London, UK.
Neuropsychiatr. 2022 Mar;36(1):19-27. doi: 10.1007/s40211-021-00390-0. Epub 2021 Apr 19.
The current study aimed to monitor psychological changes in young people (YP) with anorexia nervosa (AN) during a specialist inpatient treatment in order to explore possible predictors of an optimal length of stay. Outcome measures were analysed to determine if significant changes occur earlier or later on during the treatment.
Eating Disorder Examination Questionnaire (EDE-Q), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory (STAI) and Compulsive Exercise Test (CET) measures administered to YP (n = 42) at three time points-admission, 85% ideal body weight (IBW) and discharge-were analysed using linear mixed effects model and regression analysis to determine change between the time points and possible predictors in length of stay.
Significant improvements occurred between admission and the mid time point of 85% IBW in the eating disorder (ED) symptomology outcome measures of EDE‑Q (mean difference [MD] = 1.066 ± 0.259) and CET (MD = 1.743 ± 0.627). A significant improvement occurred in the CDI (MD = 7.714 ± 2.343), and STAI (MD = 5.292 ± 2.121) measures between admission and discharge.
Psychological changes occur at different stages of treatment. Although it was difficult to determine what factors may predict the length of stay from the variables explored, it was observed that a lower weight at admission impacted negatively on the improvement of ED and anxiety symptoms, which may lead to stay in treatment for longer. Also, higher levels of compulsive exercise and depression were associated to worse outcomes.
Evidence obtained from multiple time series with or without the intervention, such as case studies. Dramatic results in uncontrolled trials might also be regarded as this type of evidence.
本研究旨在监测神经性厌食症(AN)青少年患者在专科住院治疗期间的心理变化,以探索最佳住院时间的可能预测因素。通过分析结果来确定是否在治疗过程中更早或更晚出现显著变化。
对 42 名青少年患者(YP)在入院时、达到理想体重 85%时和出院时三个时间点进行饮食障碍检查问卷(EDE-Q)、儿童抑郁量表(CDI)、状态特质焦虑量表(STAI)和强迫性运动测试(CET)评估。采用线性混合效应模型和回归分析来确定时间点之间的变化以及住院时间的可能预测因素。
在入院至达到理想体重 85%的中期,EDE-Q(平均差异[MD] = 1.066 ± 0.259)和 CET(MD = 1.743 ± 0.627)的饮食障碍症状学结果以及 CDI(MD = 7.714 ± 2.343)和 STAI(MD = 5.292 ± 2.121)都有显著改善。
心理变化发生在治疗的不同阶段。尽管很难从所探讨的变量中确定哪些因素可能预测住院时间,但观察到入院时体重较低会对 ED 和焦虑症状的改善产生负面影响,这可能导致治疗时间延长。此外,较高的强迫性运动和抑郁水平与较差的结果相关。
证据等级 IV:从干预或不干预的多个时间序列获得的证据,如病例研究。无对照试验中的显著结果也可视为此类证据。