Key Laboratory of Applied Surface and Colloids Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, PR China.
Department of Chemistry, Taiyuan Normal University, Jinzhong 030619, PR China.
ACS Appl Mater Interfaces. 2021 Apr 28;13(16):18395-18412. doi: 10.1021/acsami.1c03758. Epub 2021 Apr 19.
Surfactant assemblies have drawn great attention in fabricating fluorescent sensors as they can provide advantages such as easy preparation, low cost, aqueous detection, high fluorescence stability, high sensitivity to external stimuli, etc. We have devoted the past few years to fluorescent cross-reactive sensors and arrays that are advantageous in differentiating similar analytes and analyzing mixed samples. In this Spotlight on Applications, we introduce our recent advances in developing surfactant assembly-based fluorescent sensors and arrays for discrimination applications. Besides using surfactant assemblies encapsulating fluorophores to fabricate multiple-element-based sensor arrays, we particularly proposed to take advantage of modulation effect of dynamic surfactant assemblies on the photophysical properties of encapsulated fluorophores to construct single-system-based discriminative sensors, which have been successfully applied in differentiation of multiple metal ions and various proteins. The applications of surfactant assembly-based sensors for the detection and discrimination of thiols, amino acids, and explosives are also introduced. Finally, the prospects of further efforts for improving surfactant ensemble sensors and their challenges are discussed.
表面活性剂组装体在制备荧光传感器方面引起了广泛关注，因为它们具有易于制备、成本低、水相检测、高荧光稳定性、对外界刺激的高灵敏度等优点。我们在过去的几年中致力于荧光交叉反应传感器和阵列的研究，这些传感器和阵列在区分相似分析物和分析混合样品方面具有优势。在本期应用聚焦中，我们介绍了我们在开发基于表面活性剂组装体的荧光传感器和阵列用于识别应用方面的最新进展。除了使用包裹荧光团的表面活性剂组装体来制备多元素传感器阵列之外，我们还特别提出利用动态表面活性剂组装体对包裹荧光团的光物理性质的调制作用来构建基于单体系的区分性传感器，该传感器已成功应用于多种金属离子和多种蛋白质的区分。还介绍了基于表面活性剂组装体的传感器在检测和区分巯基、氨基酸和爆炸物方面的应用。最后，讨论了进一步改进表面活性剂组装体传感器及其面临的挑战的前景。
