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新型曼氏血吸虫免疫层析检测试剂的初步评估。

Preliminary evaluation of a new Schistosoma Immunochromatographic Test.

机构信息

Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.

Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.

出版信息

Acta Trop. 2021 Jul;219:105893. doi: 10.1016/j.actatropica.2021.105893. Epub 2021 Apr 16.

Abstract

Over 90% of schistosomiasis infections occur in sub-Saharan Africa. A rapid ICT test would be a cheap and easy tool that could be used also in the field. We preliminarily evaluated the performance of a new Schistosoma black-latex based IgG-IgM ICT (Black-ICT) on serum samples. The results indicate a high sensitivity (98.0%) but the specificity depends on the application of a cut-off value that can discriminate between positive and negative samples. Considering a possible direct application of this test on blood from finger prick, the results are promising, providied that a signal intensity scale is developed, guiding the result interpretation.

摘要

超过 90%的血吸虫病感染发生在撒哈拉以南非洲。一种快速的信息通信技术检测方法将是一种廉价且易于使用的工具,也可在现场使用。我们初步评估了一种新的基于血吸虫黑胶乳的 IgG-IgM 信息通信技术检测试剂(黑 ICT)在血清样本中的性能。结果表明,该方法具有很高的敏感性(98.0%),但特异性取决于可以区分阳性和阴性样本的截断值的应用。考虑到该检测方法可能直接应用于手指采血,结果是有希望的,只要开发出信号强度标度来指导结果解释。

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