Department of Pharmacology, University of Oxford, Mansfield Park, Oxford OX1 3QT, UK.
Department of Pharmacology, University of Oxford, Mansfield Park, Oxford OX1 3QT, UK.
Biochim Biophys Acta Mol Cell Res. 2021 Jun;1868(7):119040. doi: 10.1016/j.bbamcr.2021.119040. Epub 2021 Apr 17.
The emergence of endo-lysosomes as ubiquitous Ca stores with their unique cohort of channels has resulted in their being implicated in a growing number of processes in an ever-increasing number of cell types. The architectural and regulatory constraints of these acidic Ca stores distinguishes them from other larger Ca sources such as the ER and influx across the plasma membrane. In view of recent advances in the understanding of the modes of operation, we discuss phagocytosis as a template for how endo-lysosomal Ca signals (generated via TPC and TRPML channels) can be integrated in multiple sophisticated ways into biological processes. Phagocytosis illustrates how different endo-lysosomal Ca signals drive different phases of a process, and how these can be altered by disease or infection.
内体溶酶体作为普遍存在的钙库，具有独特的通道群，这使得它们在越来越多的细胞类型中参与了越来越多的过程。这些酸性钙库的结构和调节限制使它们与其他较大的钙源（如内质网和质膜内流）区分开来。鉴于人们对其作用模式的理解的最新进展，我们讨论了吞噬作用，它为内体溶酶体钙信号（通过 TPC 和 TRPML 通道产生）如何以多种复杂方式整合到生物过程中提供了一个模板。吞噬作用说明了不同的内体溶酶体钙信号如何驱动一个过程的不同阶段，以及这些信号如何被疾病或感染改变。
