Krogsaeter Einar, Tang Rachel, Grimm Christian
Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany.
Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany.
Cell Calcium. 2021 Apr 14;97:102405. doi: 10.1016/j.ceca.2021.102405.
NAADP (nicotinic acid adenine dinucleotide phosphate) is a potent second messenger releasing Ca from endolysosomes through two-pore channels (TPCs) and from the endoplasmic reticulum (ER) through type 1 ryanodine receptors (RyR1). How NAADP activates these channels, whether directly or indirectly, has been a matter of debate for more than a decade. Now a protein has emerged possibly providing the missing link between TPCs/RyR1 and NAADP.
烟酰胺腺嘌呤二核苷酸磷酸（NAADP）是一种强效的第二信使，它通过双孔通道（TPCs）从内溶酶体释放钙离子，并通过1型兰尼碱受体（RyR1）从内质网（ER）释放钙离子。NAADP是直接还是间接激活这些通道，十多年来一直是一个争论的问题。现在，一种蛋白质可能出现了，它为TPCs/RyR1和NAADP之间缺失的联系提供了线索。
