夏科-莱登晶体和其他蛋白晶体驱动 2 型免疫和过敏。
Charcot-Leyden crystals and other protein crystals driving type 2 immunity and allergy.
机构信息
Immunoregulation Unit, VIB Center for Inflammation Research, Ghent, Belgium; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Unit for Structural Biology, VIB Center for Inflammation Research, Ghent, Belgium; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.
出版信息
Curr Opin Immunol. 2021 Oct;72:72-78. doi: 10.1016/j.coi.2021.03.013. Epub 2021 Apr 17.
Protein crystals derived from innate immune cells have been synonymous with a Type-2 immune response in both mouse and man for over 150 years. Eosinophilic Galectin-10 (Charcot-Leyden) crystals in humans, and Ym1/Ym2 crystals in mice are frequently found in the context of parasitic infections, but also in diseases such as asthma and chronic rhinosinusitis. Despite their notable presence, these crystals are often overlooked as trivial markers of Type-2 inflammation. Here, we discuss the source, context, and role of protein crystallization. We focus on similarities observed between Galectin-10 and Ym1/2 crystals in driving immune responses; the subsequent benefit to the host during worm infection, and conversely the detrimental exacerbation of inflammation and mucus production during asthma.
源于固有免疫细胞的蛋白质晶体在过去的 150 多年里，在小鼠和人类中一直与 2 型免疫反应同义。在人类中，嗜酸性半乳糖凝集素-10（夏科-莱登）晶体和在小鼠中 Ym1/Ym2 晶体经常在寄生虫感染的情况下被发现，但也在哮喘和慢性鼻-鼻窦炎等疾病中被发现。尽管它们的存在很明显，但这些晶体通常被忽视为 2 型炎症的琐碎标志物。在这里，我们讨论蛋白质结晶的来源、背景和作用。我们专注于观察到的半乳糖凝集素-10 和 Ym1/2 晶体在驱动免疫反应方面的相似性；随后在蠕虫感染期间对宿主的益处，以及相反地在哮喘期间炎症和黏液产生的有害恶化。
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