Zwergal Andreas, Dieterich Marianne
LMU Klinikum, Neurologische Klinik und Deutsches Schwindel- und Gleichgewichtszentrum (DSGZ).
Fortschr Neurol Psychiatr. 2021 May;89(5):211-220. doi: 10.1055/a-1432-1849. Epub 2021 Apr 19.
The 8 most frequent vestibular disorders account for more than 70% of all presentations of vertigo, dizziness, and imbalance. In acute (and mostly non-repetitive) vestibular disorders acute unilateral vestibulopathy and vestibular stroke are most important, in episodic vestibulopathies benign paroxysmal positional vertigo (BPPV), Menière's disease and vestibular migraine, and in chronic vestibular disorders bilateral vestibulopathy/presbyvestibulopathy, functional dizziness and cerebellar dizziness. In the last decade, internationally consented diagnostic criteria and nomenclature were established for the most frequent vestibular disorders, which can be easily applied in clinical practice. The diagnostic guidelines are based on history taking (including onset, duration, course, triggers, accomanying symptoms), clinical examination, and only a few apparative tests (by videooculography and audiometry) for securing the diagnosis. Treatment of vestibular disorders includes physical training (repositioning maneuvers, multimodal balance training) and pharmacological approaches (e.g., corticosteroids, antiepileptics, antidepressants, potassium-canal-blockers, drugs enhancing neuroplasticity). For most drugs, high-level evidence from prospective controlled trials is lacking. In clinical practice, the most frequent vestibular disorders can be treated effectively, thus avoiding chronicity and secondary comorbidity (by immobility, falls or psychiatric disorders such as anxiety or depression).
8种最常见的前庭疾病占所有眩晕、头晕和平衡失调症状的70%以上。在急性(且大多为非重复性)前庭疾病中,急性单侧前庭病和前庭卒中最为重要;在发作性前庭病中,良性阵发性位置性眩晕(BPPV)、梅尼埃病和前庭性偏头痛最为重要;在慢性前庭疾病中,双侧前庭病/老年前庭病、功能性头晕和小脑性头晕最为重要。在过去十年中,针对最常见的前庭疾病制定了国际公认的诊断标准和命名法,这些标准在临床实践中易于应用。诊断指南基于病史采集(包括起病、持续时间、病程、触发因素、伴随症状)、临床检查,以及仅用于确诊的少数仪器检查(通过视频眼震图和听力测定)。前庭疾病的治疗包括体能训练(复位手法、多模式平衡训练)和药物治疗方法(如皮质类固醇、抗癫痫药、抗抑郁药、钾通道阻滞剂、增强神经可塑性的药物)。对于大多数药物而言,缺乏前瞻性对照试验的高级别证据。在临床实践中,最常见的前庭疾病可以得到有效治疗,从而避免病情慢性化和继发合并症(因活动减少、跌倒或焦虑或抑郁等精神障碍)。