George R B
Department of Medicine, Louisiana State University Medical Center, Shreveport 71130-3932.
Postgrad Med. 1988 Jul;84(1):185-6, 189, 192-4. doi: 10.1080/00325481.1988.11700346.
The pathogenic and opportunistic fungi that commonly infect the human respiratory system cause diseases such as histoplasmosis, blastomycosis, aspergillosis, and invasive candidiasis. The increase in the incidence and severity of mycotic infections due to more aggressive immunosuppressive therapy and the spread of acquired immunodeficiency syndrome (AIDS) has had an impact on diagnosis and treatment of these conditions. Several therapeutic agents are currently available or undergoing clinical trials in the treatment of the pulmonary mycoses; among the agents with the greatest potential usefulness are the oral imidazoles, ketoconazole, itraconazole, and fluconazole.
通常感染人类呼吸系统的致病性和机会性真菌会引发组织胞浆菌病、芽生菌病、曲霉病和侵袭性念珠菌病等疾病。由于更积极的免疫抑制治疗以及获得性免疫缺陷综合征（艾滋病）的传播，真菌感染的发病率和严重程度有所增加，这对这些疾病的诊断和治疗产生了影响。目前有几种治疗药物可用于治疗肺部真菌病或正在进行相关临床试验；其中最具潜在效用的药物包括口服咪唑类药物酮康唑、伊曲康唑和氟康唑。
