Tanwar S, Mattoo B, Kumar U, Dada R, Bhatia R
Department of Physiology, All India Institute of Medical Sciences (AIIMS), New Delhi.
Department of Rheumatology, All India Institute of Medical Sciences (AIIMS), New Delhi.
Reumatismo. 2021 Apr 19;73(1):24-31. doi: 10.4081/reumatismo.2021.1312.
Genetic predisposition may play an important role in the development of fibromyalgia syndrome (FMS). Serotonin is known to be involved in pain modulation and serotonin-1A receptor plays a considerable role in determining the central 5-HT tone. Consequently, variation in 5-HT1A receptor gene (HTR1A) may be responsible for inter-individual variability in pain sensitivity and other clinical symptoms of FMS. Therefore, the objectives of this research work were to study the gene polymorphism of 5-HTR1A gene and to explore the correlation between rs6295 genotype (-1019C/G HTR1A) and duration of pain, pain intensity and pain related depression and anxiety, if any, in FMS. 5-HTR1A genotype for the C(-1019)G polymorphism was typed in 62 patients with FMS and 42 healthy subjects. Present pain intensity, components of pain and pain related depression and anxiety were assessed using the numerical pain rating scale, McGill pain questionnaire and Hamilton depression and anxiety rating scale respectively. 5-HTR1A gene was represented by three different genotypes, homozygous C/C, heterozygous C/G and homozygous G/G. Analysis of the 5-HTR1A gene showed a frequency of 58%, 31% and 11% for the C/C, C/G and G/G genotypes, respectively in FMS group. This proportion was 69%, 23% and 8% in healthy subjects. No significant correlation was observed between 5-HTR1A gene polymorphism and pain and related symptoms in FMS patients. To the best of our knowledge this is the first study which investigated the correlation between the 5-HTR1A gene polymorphism and pain intensity, the affective component of pain, pain related depression and anxiety in FMS.
遗传易感性可能在纤维肌痛综合征（FMS）的发病中起重要作用。已知血清素参与疼痛调节，血清素-1A受体在决定中枢5-羟色胺（5-HT）水平方面发挥着重要作用。因此，5-HT1A受体基因（HTR1A）的变异可能导致个体间疼痛敏感性及FMS其他临床症状的差异。因此，本研究的目的是研究5-HTR1A基因的多态性，并探讨rs6295基因型（-1019C/G HTR1A）与FMS患者疼痛持续时间、疼痛强度以及疼痛相关抑郁和焦虑之间的相关性（如有）。对62例FMS患者和42名健康受试者进行了5-HTR1A基因C（-1019）G多态性的基因分型。分别使用数字疼痛评分量表、麦吉尔疼痛问卷以及汉密尔顿抑郁和焦虑评分量表评估当前疼痛强度、疼痛成分以及疼痛相关抑郁和焦虑。5-HTR1A基因由三种不同基因型表示，即纯合子C/C、杂合子C/G和纯合子G/G。FMS组中5-HTR1A基因分析显示，C/C、C/G和G/G基因型的频率分别为58%、31%和11%。健康受试者中的这一比例分别为69%、23%和8%。未观察到FMS患者5-HTR1A基因多态性与疼痛及相关症状之间存在显著相关性。据我们所知，这是第一项研究5-HTR1A基因多态性与FMS患者疼痛强度、疼痛情感成分、疼痛相关抑郁和焦虑之间相关性的研究。
