Cardiovascular and Mitochondria Related Diseases Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Department of Research and Development, Vels Publisher, Bodinayakanur, Tamil Nadu, India.
Curr Med Chem. 2021 Oct 25;28(33):6895-6914. doi: 10.2174/0929867328666210419125032.
Ferroptosis plays a critical regulatory role as a new kind of cell death, initiating and developing an array of disorders like neurological diseases, acute injury of kidney, tumors, and ischemia, etc. Although selective deposition of iron is one of the pathogenic reasons for PD, it's underlying mechanism is still unknown. In this review, the role of neuroinflammation in Parkinson's disease (PD) leading to neurodegeneration has been discussed in detail. The accumulation of brain iron has been found in many chronic neurological disorders, including PD. We have also discussed the unique features of ferroptosis , and it links in aggravating the pathology of PD. Further, the concept of targeting ferroptosis for PD pathology and inducers and inhibitors, pharmacological drugs and clinical trials for PD candidates in phase IV stage in completed status are detailed in the respective sections.
铁死亡作为一种新型的细胞死亡方式，在神经退行性疾病、肾急性损伤、肿瘤、缺血等多种疾病的发生和发展中起着关键的调控作用。虽然铁的选择性沉积是 PD 的致病原因之一，但其中的机制仍不清楚。在本综述中，详细讨论了神经炎症在导致神经退行性变的帕金森病（PD）中的作用。在许多慢性神经疾病中，包括 PD，都发现了脑铁的积累。我们还讨论了铁死亡的独特特征，以及它在加重 PD 病理中的作用。此外，还详细讨论了针对 PD 病理的铁死亡靶点，以及铁死亡诱导剂和抑制剂、针对 PD 的候选药物在第四阶段的临床试验状态。
