Ray A, Henke P G, Sullivan R M
Department of Psychology, St. Francis Xavier University, Antigonish, Nova Scotia, Canada.
Physiol Behav. 1988;42(4):359-64. doi: 10.1016/0031-9384(88)90277-6.
Acute treatments with haloperidol (1 mg/kg), clozapine (10 mg/kg) and metoclopramide (10 mg/kg) significantly facilitated cold-restraint-induced gastric ulcer formation in rats. In addition, haloperidol and clozapine also produced gastric mucosal erosions in non-stressed rats. Bilateral lesions of the ventral tegmental area (VTA) and substantia nigra also aggravated stress ulcerogenesis--VTA lesions also being effective in inducing gastric ulcers in non-stressed rats. Long-term treatment with dopaminergic blockers showed variable effects. Clozapine potentiated the gastric stress pathology, whereas no significant facilitation was observed with haloperidol or metoclopramide. In addition, withdrawal from haloperidol did not influence the gastric ulcer formation when compared to controls. The role of central dopaminergic involvement in gastric stress pathology is discussed in light of the present results.
用氟哌啶醇（1毫克/千克）、氯氮平（10毫克/千克）和胃复安（10毫克/千克）进行急性治疗，显著促进了冷束缚诱导的大鼠胃溃疡形成。此外，氟哌啶醇和氯氮平在未应激的大鼠中也产生了胃黏膜糜烂。腹侧被盖区（VTA）和黑质的双侧损伤也加重了应激性溃疡的发生——VTA损伤在未应激的大鼠中也能有效诱导胃溃疡。长期使用多巴胺能阻滞剂治疗显示出不同的效果。氯氮平增强了胃应激病理反应，而氟哌啶醇或胃复安未观察到显著的促进作用。此外，与对照组相比，停用氟哌啶醇不影响胃溃疡的形成。根据目前的结果讨论了中枢多巴胺能参与胃应激病理的作用。
