Faculty of Medicine, Beni -Suef University, Beni - Suef, Egypt.
BMC Anesthesiol. 2021 Apr 19;21(1):122. doi: 10.1186/s12871-021-01340-7.
This study compared the effects of premedication with different doses of aminophylline on the recovery profile after general anaesthesia.
Forty-five patients scheduled for pelvic-abdominal surgeries were divided into 3 groups: Group C: the patients received 100 ml of IV normal saline, Group A1: the patients received 2 mg/kg IV aminophylline, and Group A2: the patients received 4 mg/kg IV aminophylline 30 min before induction of general anaesthesia. The following data were recorded: demographic data, ASA physical status, duration of anaesthesia and surgery, heart rate, mean arterial blood pressure, propofol dose, fentanyl dose, times to reach BIS (48 ± 2) after induction of anaesthesia and to reach a value of 80 after discontinuation of sevoflurane anaesthesia, time to recovery of consciousness and to tracheal extubation and to discharge from the post-anaesthesia care unit, and side effects of aminophylline.
The time to reach a BIS of 48 ± 2 was significantly lower for the control group than group A2 (70.67 ± 22.50 and 106.67 ± 34.77 s for groups C and A2, respectively, p -value =0.01). The time to reach a BIS of 80 was significantly longer for the control group than group A1 andA2 (5.6 ± 1.40,3.5 ± 1.93and 2.53 ± 1.72 min for groups C,A1 and A2, respectively, p -value < 0.01). The time to ROC was significantly longer for the control group than groups A1 and A2 (8.93 ± 0.92, 5.6 ± 2.47 and 4.53 ± 3.33 min for groups C, A1 and A2, respectively; p -value < 0.01). The extubation time was significantly longer for the control group than groups A1 and A2 (12.4 ± 1.08, 7.87 ± 3.27 and 6.6 ± 2.47 min for groups C, A1 and A2, respectively; p -value < 0.01).
Premedication with aminophylline enhanced the recovery profile after pelvic-abdominal surgeries under general anaesthesia without cardiovascular complications.
Name of the registry: Register@ClinicalTrials.gov Trial registration number: ClinicalTrials.gov Identifier: NCT04151381. Date of registration, November 5, 2019, 'Retrospectively registered'.
本研究比较了不同剂量氨茶碱预处理对全身麻醉后恢复情况的影响。
45 名计划行盆腔-腹部手术的患者被分为 3 组：C 组：患者接受 100ml 静脉生理盐水；A1 组：患者接受 2mg/kg 静脉氨茶碱；A2 组：患者在全身麻醉诱导前接受 4mg/kg 静脉氨茶碱。记录以下数据：人口统计学数据、ASA 身体状况、麻醉和手术持续时间、心率、平均动脉压、异丙酚剂量、芬太尼剂量、麻醉诱导后达到 BIS（48±2）的时间以及停止七氟醚麻醉后达到 80 的时间、意识恢复和拔管以及离开麻醉后护理单位的时间以及氨茶碱的副作用。
与 A2 组相比，C 组达到 BIS 48±2 的时间明显更短（C 组和 A2 组分别为 70.67±22.50 和 106.67±34.77s，p 值=0.01）。C 组达到 BIS 80 的时间明显长于 A1 组和 A2 组（C 组、A1 组和 A2 组分别为 5.6±1.40、3.5±1.93 和 2.53±1.72min，p 值<0.01）。C 组恢复意识的时间明显长于 A1 组和 A2 组（C 组、A1 组和 A2 组分别为 8.93±0.92、5.6±2.47 和 4.53±3.33min，p 值<0.01）。C 组拔管时间明显长于 A1 组和 A2 组（C 组、A1 组和 A2 组分别为 12.4±1.08、7.87±3.27 和 6.6±2.47min，p 值<0.01）。
全身麻醉下盆腔-腹部手术后氨茶碱预处理可改善恢复情况，无心血管并发症。
注册名称：Register@ClinicalTrials.gov 试验注册编号：ClinicalTrials.gov 标识符：NCT04151381。注册日期，2019 年 11 月 5 日，“回顾性注册”。
