Biomedical Research Lab, Department of Mechanical Engineering, Indian Institute of Technology, Kanpur 208016, India.
J Nanosci Nanotechnol. 2021 Oct 1;21(10):5026-5035. doi: 10.1166/jnn.2021.19370.
In this work, the effect of varying content of B₂O₃ with respect to SiO₂ on mechanical and bioactivity properties have been evaluated for borosilicate bioactive glasses containing SiO₂, B₂O₃, CaO and P₂O. The bioactive glasses have been synthesized using the sol-gel technique. The synthesized glasses were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and Field Emission Scanning electron microscopy (FESEM). These bioactive glasses were fabricated as scaffolds by using polymer foam replication method. Subsequently, in bioactivity evaluation of borosilicate bioactive glass was done. Based on the XRD and energy-dispersive X-ray spectroscopy (EDS) results showing good apatite-formation ability when soaked in simulated body fluid (SBF), one of the bioactive glass (BG-B30 containing 30 mol% B₂O₃) was selected for further study. The compressive strength of the bioactive glass scaffolds was within the range of trabecular bone. However, it was found near the lower limit of the trabecular bone (0.2-12 MPa). Therefore, BG-B30 scaffold was reinforced with carbon nanotubes (CNTs) to allow for mechanical manipulation during tissue engineering applications. The compressive strength increased from 1.05 MPa to 7.42 MPa (a 606% increase) after reinforcement, while the fracture toughness rose from 0.12 MPa √ m to 0.45 MPa √ m (a 275% increase). Additionally, connectivity of the pores in the CNT reinforced BG-B30 scaffolds were evaluated and the pores were found to be well connected. The evaluated properties of the fabricated scaffolds demonstrate their potential as a synthetic graft for possible application in bone tissue engineering.
在这项工作中，我们研究了含有 SiO₂、B₂O₃、CaO 和 P₂O 的硼硅酸盐生物活性玻璃中 B₂O₃ 相对于 SiO₂ 的含量变化对机械性能和生物活性的影响。采用溶胶-凝胶技术合成了这些生物活性玻璃。通过 X 射线衍射（XRD）、傅里叶变换红外（FTIR）光谱和场发射扫描电子显微镜（FESEM）对合成的玻璃进行了表征。这些生物活性玻璃通过聚合物泡沫复制法制成支架。随后，对硼硅酸盐生物活性玻璃的生物活性进行了评价。基于 XRD 和能量色散 X 射线能谱（EDS）结果表明，在模拟体液（SBF）中具有良好的磷灰石形成能力，选择其中一种生物活性玻璃（BG-B30，含有 30mol%B₂O₃）进行进一步研究。生物活性玻璃支架的抗压强度在松质骨范围内。然而，发现它接近松质骨的下限（0.2-12MPa）。因此，用碳纳米管（CNTs）增强 BG-B30 支架，以便在组织工程应用中进行机械操作。增强后，抗压强度从 1.05MPa 增加到 7.42MPa（增加了 606%），而断裂韧性从 0.12MPa √ m 增加到 0.45MPa √ m（增加了 275%）。此外，还评估了 CNT 增强 BG-B30 支架中孔的连通性，发现孔连接良好。所制备支架的评估性能表明，它们有可能作为一种合成移植物，用于可能的骨组织工程应用。
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