Department of Mechanical Engineering, Indian Institute of Technology, Kanpur 208016, India.
J Nanosci Nanotechnol. 2019 May 1;19(5):2738-2746. doi: 10.1166/jnn.2019.16029.
45S5 Bioglass® has been used quite extensively in the form of particulate as synthetic bone graft. However, 45S5 glass has certain limitations such as difficulty in sintering and slow and partial conversion to hydroxy carbonated apatite. In pursuit of overcoming these limitations, bioactive glasses (13-93B1) containing increased amount of B₂O₃ by partial replacement of SiO₂ have been prepared using sol-gel technique in this study. Since bioactive glasses are brittle in nature, therefore, they are unsuitable for load bearing sites. Consequently, 3D porous scaffolds by reinforcement with varying weight percent of carbon nanotubes (CNTs) have been fabricated in this work by physical mixing and polymer foam replication technique. Compared with pure 13-93B1 bioactive glasses, addition of 0.2 weight percent of CNT resulted in maximum increase in compressive strength from 1.80 MPa to 5.84 MPa (a 224% increase) and elastic modulus from 102 MPa to 269.4 MPa (a 164% increase), respectively. Bioactivity of these scaffolds was confirmed using simulated body fluid test for 28 days. The compressive strength post-SBF studies were within the range of compressive strength of trabecular bone. These results show potential of fabricating a 3D porous scaffold with sufficient strength and biocompatibility using CNT-1393B1 bioactive glasses.
45S5 生物玻璃®已被广泛用作颗粒状的合成骨移植物。然而，45S5 玻璃存在一些局限性，如烧结困难、羟碳酸磷灰石转化缓慢且不完全。为了克服这些局限性，本研究采用溶胶-凝胶技术制备了含有更多 B₂O₃的生物活性玻璃（13-93B1），通过部分取代 SiO₂。由于生物活性玻璃本质上是脆性的，因此它们不适合承重部位。因此，本工作通过物理混合和聚合物泡沫复制技术，用不同重量百分比的碳纳米管（CNT）增强制备了 3D 多孔支架。与纯 13-93B1 生物活性玻璃相比，添加 0.2wt%的 CNT 可使抗压强度从 1.80MPa 增加到 5.84MPa（增加 224%），弹性模量从 102MPa 增加到 269.4MPa（增加 164%）。使用模拟体液测试对这些支架进行了 28 天的生物活性测试。SBF 研究后的抗压强度在小梁骨的抗压强度范围内。这些结果表明，使用 CNT-1393B1 生物活性玻璃制造具有足够强度和生物相容性的 3D 多孔支架具有潜力。
