Elwehidy Ahmed S, Mokbel Tharwat, Abouelkheir Hossam Youssef, Samra Waleed Abou, Wagdy Faried M, Abdelkader Amr Mohammed Elsayed
Department of Ophthalmology, Mansoura Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
Department of Ophthalmology, Faculty of Medicine, Menofia University, Shebin El Kom 32512, Egypt.
Int J Ophthalmol. 2021 Apr 18;14(4):510-516. doi: 10.18240/ijo.2021.04.05. eCollection 2021.
To evaluate the safety and efficacy of augmented trabeculotomy with Ologen versus perfluoropropane in management of pseudophakic glaucoma.
This is a comparative randomized study included 57 pseudophakic eyes of 57 patients with medically uncontrolled open angle glaucoma (OAG). Twenty-nine patients were allocated in group I (trabeculectomy with Ologen; trab-ologen group), while 28 patients were assigned in group II (trabeculectomy with perfluoropropane gas bubble; trab-C3F8 gas bubble group).
The intraocular pressure (IOP) was significantly reduced in both study groups at all postoperative follow up intervals (1wk, 3, 6, 12, 18, 24, 30 and 36mo, <0.001). The differences between the mean IOP values of both groups remained statistically insignificance during the early 12 months of follow up. However, the trab-ologen group achieved a statistically significant reduction over the trab-C3F8 gas bubble group during the last 24 months of follow up.
Augmentation of trabeculectomy with either Ologen implant or perfluoropropane gas bubble are associated with strict long term IOP control and evident safety in medically-uncontrolled pseudophakic eyes with OAG.
评估在治疗人工晶状体性青光眼时，使用奥洛凝胶（Ologen）辅助小梁切开术与使用全氟丙烷相比的安全性和有效性。
这是一项比较性随机研究，纳入了57例药物治疗无法控制的开角型青光眼（OAG）患者的57只人工晶状体眼。29例患者被分配到第一组（奥洛凝胶辅助小梁切除术；奥洛凝胶组），而28例患者被分配到第二组（全氟丙烷气泡辅助小梁切除术；全氟丙烷气泡组）。
在所有术后随访间隔（1周、3、6、12、18、24、30和36个月，P<0.001），两个研究组的眼压（IOP）均显著降低。在随访的前12个月，两组平均眼压值之间的差异在统计学上无显著性。然而，在随访的最后24个月，奥洛凝胶组的眼压降低幅度在统计学上显著高于全氟丙烷气泡组。
对于药物治疗无法控制的人工晶状体性开角型青光眼患者，使用奥洛凝胶植入物或全氟丙烷气泡辅助小梁切除术均与严格的长期眼压控制和明显的安全性相关。
