Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Mail Stop B179, 12631 E. 17th Avenue, Room 8111, Aurora, CO, 80045, USA.
VA Eastern Colorado Geriatric Research, Education, and Clinical Center (GRECC), VA Eastern Colorado Health Care System, Aurora, CO, 80045, USA.
Eur J Appl Physiol. 2021 Aug;121(8):2187-2192. doi: 10.1007/s00421-021-04691-8. Epub 2021 Apr 19.
Non-steroidal anti-inflammatory drugs (NSAIDs) taken before exercise have been shown to impair bone formation. NSAIDs also suppress inflammatory cytokines, such as interleukin-6 (IL-6), that can have pro-resorptive effects. It is unclear how taking NSAIDs timed around exercise influences inflammatory and bone biomarkers following an acute exercise bout in older adults.
To determine if timing of ibuprofen use relative to a single exercise bout has acute effects on serum IL-6, bone-specific alkaline phosphatase (BAP, marker of bone formation), and c-telopeptide of type I collagen (CTX, marker of bone resorption).
As part of a 36-week exercise intervention, participants aged 60 to 75 years were randomized to 3 groups: placebo before and after exercise (PP), ibuprofen before and placebo after exercise (IP), or placebo before and ibuprofen after exercise (PI). Acute responses were studied in a subset of participants (12 PP, 17 IP, 13 PI). Blood was sampled before and immediately, 30 min, and 60 min after exercise for IL-6, BAP, and CTX.
The exercise-induced increase in IL-6 was blunted in response to IP when compared to PI 60-min after exercise (p < 0.001). There were no significant differences in the change in BAP or CTX between groups at any time points CONCLUSION: Ibuprofen taken before exercise dampened the inflammatory response to exercise but had no effects on bone biomarkers in older adults. It may be necessary to monitor changes for a longer time interval after an acute exercise bout to determine whether bone turnover is altered by ibuprofen or other NSAIDs.
ClinicalTrials.gov: NCT00462722; Posted 04/19/2007.
研究表明，运动前服用非甾体类抗炎药（NSAIDs）会损害骨形成。NSAIDs 还会抑制白细胞介素-6（IL-6）等炎症细胞因子，这些细胞因子可能具有促进骨吸收的作用。目前尚不清楚在老年人中，围绕运动时间服用 NSAIDs 会如何影响急性运动后炎症和骨生物标志物。
确定在单次运动期间使用布洛芬的时间安排是否对老年人血清 IL-6、骨特异性碱性磷酸酶（BAP，骨形成标志物）和 I 型胶原 C 端肽（CTX，骨吸收标志物）有急性影响。
作为 36 周运动干预的一部分，年龄在 60 至 75 岁的参与者被随机分为 3 组：运动前后服用安慰剂（PP）、运动前后服用布洛芬和安慰剂（IP）或运动前后服用安慰剂和布洛芬（PI）。在一部分参与者（12 名 PP、17 名 IP、13 名 PI）中进行了急性反应研究。在运动前和运动后即刻、30 分钟和 60 分钟采集血液样本，用于检测 IL-6、BAP 和 CTX。
与 PI 相比，IP 组运动后 60 分钟时，IL-6 的运动诱导增加受到抑制（p<0.001）。在任何时间点，BAP 或 CTX 的变化在各组之间均无显著差异。
运动前服用布洛芬抑制了运动对炎症反应，但对老年人的骨生物标志物没有影响。可能需要在急性运动后更长的时间间隔内监测变化，以确定布洛芬或其他 NSAIDs 是否改变了骨转换。
ClinicalTrials.gov：NCT00462722；2007 年 4 月 19 日发布。
