Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
J Neurovirol. 2021 Jun;27(3):507-509. doi: 10.1007/s13365-021-00979-9. Epub 2021 Apr 19.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents respiratory symptoms as the most common clinical manifestations. Similar to some other viral infections, it can cause severe neurological damages. Here, we describe a 40-year-old man case who initially was admitted to a major hospital with presenting 7 days with weak flu-like symptoms (cough) and fever then presented neurology signs for 3 days. Physical examination and brain magnetic resonance imaging (MRI) showed cerebral vasculopathy. Molecular testing was performed on nasopharyngeal swab by real-time reverse transcription polymerase chain reaction (RT-PCR) which was positive for SARS-CoV-2. The patient received supportive cares and was treated with routine antiplatelet therapy. He was improved and discharged 10 days after admission with no symptoms. Our findings report a 40-year-old man with flu-like symptoms that indicate cerebral vasculopathy that was discharged with no symptoms. Therefore, physicians should be monitor patients with worsening or progressive central nervous system results. The pathobiology of this virus is still incompletely known; therefore, extensive studies are needed to reveal the effect of COVID-19 on the nervous system.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的最常见临床表现为呼吸道症状。与其他一些病毒感染类似，它可导致严重的神经损伤。在这里，我们描述了一例 40 岁男性病例，他最初因出现 7 天类似流感的轻度症状（咳嗽）和发热而被一家大医院收治，随后出现了 3 天的神经系统症状。体格检查和脑磁共振成像（MRI）显示脑血管病。通过实时逆转录聚合酶链反应（RT-PCR）对鼻咽拭子进行了分子检测，结果 SARS-CoV-2 阳性。患者接受了支持性护理，并接受了常规抗血小板治疗。他在入院后 10 天症状改善并出院。我们的发现报告了一例 40 岁男性，有类似流感的症状，表明存在脑血管病，且无任何症状出院。因此，医生应监测出现中枢神经系统症状恶化或进展的患者。该病毒的发病机制尚不完全清楚；因此，需要进行广泛的研究以揭示 COVID-19 对神经系统的影响。
