School of Life Sciences & Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, P.R. China.
Epigenomics. 2021 May;13(9):699-713. doi: 10.2217/epi-2020-0449. Epub 2021 Apr 20.
Although studies on lncRNAs in renal fibrosis have focused on target genes and functions of lncRNAs, a comprehensive interaction analysis of lncRNAs is lacking. Differentially expressed genes in renal fibrosis were screened, and the interaction between lncRNAs and miRNAs was searched. We constructed a ceRNA network associated with renal fibrosis, by which we found the transcription factor Creb5, a target gene of lncRNA Gas5 that might regulate extracellular Fn1 deposition. Our study not only provides a theoretical basis for the ceRNA regulation mechanism of Gas5 but also provides experimental evidence supporting the use of Gas5 targeting in the treatment of renal fibrosis.
虽然关于 lncRNA 在肾纤维化中的研究主要集中在 lncRNA 的靶基因和功能上，但缺乏对 lncRNA 的综合相互作用分析。本研究筛选肾纤维化差异表达基因，搜索 lncRNA 与 miRNA 的相互作用，构建与肾纤维化相关的 ceRNA 网络，发现转录因子 Creb5 是 lncRNA Gas5 的靶基因，可能调节细胞外 Fn1 沉积。我们的研究不仅为 Gas5 的 ceRNA 调控机制提供了理论依据，也为 Gas5 靶向治疗肾纤维化提供了实验证据。
