Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medical, Southeast University, Nanjing, China.
Department of Psychology, Georgia State University, Atlanta, USA.
Behav Brain Res. 2021 Jul 9;409:113310. doi: 10.1016/j.bbr.2021.113310. Epub 2021 Apr 18.
Our previous study identified a significant association between a single nucleotide polymorphism (SNP) located in the neurogenin3 (NEUROG3) gene and post-stroke depression (PSD) in Chinese populations. The present work explores whether polymorphism rs144643855 affects regional brain activity and clinical phenotypes in major depressive disorder (MDD).
A total of 182 participants were included: 116 MDD patients and 66 normal controls. All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scanning at baseline. Spontaneous brain activity was assessed using amplitude of low-frequency fluctuation (ALFF). The Hamilton Depression Scale-24 (HAMD-24) and Snaith-Hamilton Pleasure Scale (SHAPS) were used to assess participants at baseline. Two-way analysis of covariance (ANCOVA) was used to explore the interaction between diagnostic groups and NEUROG3 rs144643855 on regional brain activity. We performed correlation analysis to further test the association between these interactive brain regions and clinical manifestations of MDD.
Genotype and disease significantly interacted in the left inferior frontal gyrus (IFG-L), right superior frontal gyrus (SFG-R), and left paracentral lobule (PCL-L) (P < 0.05). ALFF values of the IFG-L were found to be significantly associated with anhedonia in MDD patients.
These findings suggest a potential relationship between rs144643855 variations and altered frontal brain activity in MDD. NEUROG3 may play an important role in the neuropathophysiology of MDD.
我们之前的研究发现，位于神经基因 3（NEUROG3）基因中的一个单核苷酸多态性（SNP）与中国人卒中后抑郁（PSD）显著相关。本研究旨在探讨多态性 rs144643855 是否会影响重度抑郁症（MDD）患者的局部脑活动和临床表型。
共纳入 182 名参与者：116 名 MDD 患者和 66 名正常对照。所有参与者在基线时均接受静息态功能磁共振成像（rs-fMRI）扫描。使用低频振幅（ALFF）评估自发脑活动。在基线时使用汉密尔顿抑郁量表-24 项（HAMD-24）和 Snaith-Hamilton 愉悦量表（SHAPS）评估参与者。采用双因素方差分析（ANCOVA）来探讨诊断组和 NEUROG3 rs144643855 之间对局部脑活动的交互作用。我们进行了相关分析，以进一步测试这些交互脑区与 MDD 临床表现之间的关联。
基因型和疾病在左侧额下回（IFG-L）、右侧额上回（SFG-R）和左侧旁中央小叶（PCL-L）中显著相互作用（P<0.05）。IFG-L 的 ALFF 值与 MDD 患者的快感缺失显著相关。
这些发现提示 rs144643855 变异与 MDD 患者额叶脑活动改变之间存在潜在关系。NEUROG3 可能在 MDD 的神经病理生理学中发挥重要作用。
