Grassi Guido, Quarti-Trevano Fosca, Dell'oro Raffaella, Cuspidi Cesare, Mancia Giuseppe
Department of Medicine and Surgery, Medical Clinic, University of Milano-Bicocca, Monza, Monza-Brianza, Italy -
Department of Medicine and Surgery, Medical Clinic, University of Milano-Bicocca, Monza, Monza-Brianza, Italy.
Panminerva Med. 2021 Dec;63(4):430-435. doi: 10.23736/S0031-0808.21.04396-2. Epub 2021 Apr 20.
Among the observational studies performed in the area of blood pressure measurements in the population the "Pressioni Arteriose Monitorate E Loro Associazioni" (PAMELA) investigation represents a unique research for several reasons. The PAMELA study combines clinic, home and 24-hour blood pressure measurements in all participants, which were representative of the general population. Examination included metabolic variables, allowing us to determine the interrelationships between blood pressure and metabolic profile. The protocol also included evaluation of organ damage, such as left ventricular hypertrophy, left ventricular diastolic dysfunction, left atrial dimensions and aortic root diameters. Finally, PAMELA represents one of the few studies with a prolonged follow-up, the last survey being completed three years ago, and data collected are under analysis. This will allow to update the information related to cardiovascular morbidity and mortality in the study cohort. The present paper provided an overview of the various scientific contributions of the PAMELA study to the epidemiology, pathophysiology and clinical aspects of hypertension and hypertension related cardiovascular risk.
在针对人群血压测量领域开展的观察性研究中，“动脉压监测及其关联”（PAMELA）调查因其若干原因而堪称一项独特的研究。PAMELA研究对所有参与者进行了诊所、家庭及24小时血压测量，这些参与者代表了普通人群。检查涵盖代谢变量，使我们能够确定血压与代谢状况之间的相互关系。该方案还包括对器官损害的评估，如左心室肥厚、左心室舒张功能障碍、左心房大小及主动脉根部直径。最后，PAMELA是为数不多的进行了长期随访的研究之一，最近一次调查于三年前完成，所收集的数据正在分析中。这将有助于更新研究队列中与心血管发病率和死亡率相关的信息。本文概述了PAMELA研究在高血压及高血压相关心血管风险的流行病学、病理生理学和临床方面所做出的各种科学贡献。
