1McMaster University Department of Family Medicine, Hamilton, Ontario, Canada.
Sr Care Pharm. 2021 May 1;36(5):228-237. doi: 10.4140/TCP.n.2021.228.
Every drug review for older people should consider which medicines to continue, but equally important, which medicines can be discontinued. As we age, the balance between potential benefits and potential risks of medications often shifts towards more harm. For example, antidepressants are commonly prescribed in general, but in the older person, they carry specific potential harms. Further, there is data indicating that a substantial proportion of users have no evidence-based indications to continue antidepressants and could be candidates to try stopping treatment. We outline first the imperatives and evidence for deprescribing antidepressants and then finally the practical approaches to deprescribing.
对于老年人的每一种药物评估都应该考虑继续使用哪些药物，但同样重要的是，哪些药物可以停用。随着年龄的增长，药物的潜在益处和潜在风险之间的平衡往往会向更多危害的方向倾斜。例如，抗抑郁药通常在一般情况下开处方，但在老年人中，它们有特定的潜在危害。此外，有数据表明，相当一部分使用者没有继续使用抗抑郁药的基于证据的指征，可以尝试停止治疗。我们首先概述了停用抗抑郁药的必要性和证据，最后介绍了停用抗抑郁药的实用方法。
