Department of Pediatrics, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Community Medicine Research Center, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Department of Pediatrics, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Community Medicine Research Center, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Pediatric Pulmonology, College of Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
J Microbiol Immunol Infect. 2022 Apr;55(2):300-306. doi: 10.1016/j.jmii.2021.03.016. Epub 2021 Apr 9.
Serum or cord blood soluble Fas ligand (FasL) has been related to asthma, allergic rhinitis, and atopic dermatitis in cross-sectional and short-term follow-up studies. However, the association of cord blood soluble FasL with long-term allergic outcomes has seldom been investigated.
The Prediction of Allergies in Taiwanese Children birth cohort study recruited healthy newborns upon delivery. At birth, blood was collected from the umbilical cords of these children, and the cord blood soluble Fas ligand levels were measured. At the age of seven years, the allergic outcome of each child was diagnosed by pediatric allergists and pulmonologists. Tests were conducted to measure the specific immunoglobulin E, fractional exhaled nitric oxide (FeNO), and pulmonary function levels of each child.
Cord blood soluble FasL levels were higher in seven-year-old children with allergic rhinitis (Odds ratio [OR] = 2.41, p = 0.012) and expiratory airway obstruction (the highest forced expiratory volume in 1 second/forced vital capacity < 90%, OR = 2.11, p = 0.022). The FeNO and Dermatophagoides pteronyssinus-specific immunoglobulin E levels of seven-year-old children were positively correlated with cord blood soluble FasL levels (p = 0.006 and 0.02, respectively).
In this birth cohort, the cord blood soluble FasL levels were associated with allergic rhinitis, obstructive-type lung function, FeNO, and house dust mite sensitization in 7-year-old children. The cord blood soluble FasL level might be used as a predictor for allergic diseases in children who are 7 years old.
血清或脐血可溶性 Fas 配体（FasL）与哮喘、变应性鼻炎和特应性皮炎的横断面和短期随访研究有关。然而，脐血可溶性 FasL 与长期过敏结局的相关性很少被研究。
台湾儿童过敏预测出生队列研究在分娩时招募了健康的新生儿。在出生时，从这些儿童的脐带中采集血液，并测量脐带血可溶性 FasL 水平。在 7 岁时，由儿科过敏症专家和肺病专家诊断每个儿童的过敏结局。对每个儿童进行特异性免疫球蛋白 E、呼出气一氧化氮（FeNO）和肺功能检测。
患有过敏性鼻炎（比值比 [OR] = 2.41，p = 0.012）和呼气气道阻塞（最高 1 秒用力呼气量/用力肺活量 <90%，OR = 2.11，p = 0.022）的 7 岁儿童的脐带血可溶性 FasL 水平较高。7 岁儿童的 FeNO 和户尘螨特异性免疫球蛋白 E 水平与脐带血可溶性 FasL 水平呈正相关（p = 0.006 和 0.02）。
在这个出生队列中，脐带血可溶性 FasL 水平与 7 岁儿童的变应性鼻炎、阻塞型肺功能、FeNO 和屋尘螨致敏有关。脐带血可溶性 FasL 水平可作为 7 岁儿童过敏疾病的预测指标。
