Homerton University Hospital, NHS Foundation Trust, London, UK.
Centre for Genomics and Child Health, Queen Mary University of London, London, UK.
Pediatr Res. 2021 Aug;90(2):267-271. doi: 10.1038/s41390-021-01479-6. Epub 2021 Apr 20.
The COVID-19 pandemic poses many direct and indirect consequences for children's health and associated research. Direct consequences include participation of children in COVID-19 research trials, pausing other research in children and the potential implications of a global economic downturn on future research funding. Collaborative and networked research together with streamlined research processes and use of remote technology have been central to efforts by clinicians and scientists around the world and have proved essential for reducing COVID-19 morbidity and mortality. IMPACT: Maintain streamlined and efficient approaches to research governance and data sharing to facilitate high-quality collaborative research. Ensure early inclusion of children in trials of therapies for diseases that affect all age groups. Paediatric Research Societies should co-ordinate effective processes to define key research questions and develop multinational clinical trials for diagnostics, therapeutics and preventative strategies for infants, children and young people.
COVID-19 大流行给儿童健康和相关研究带来了许多直接和间接的后果。直接后果包括儿童参与 COVID-19 研究试验、暂停儿童的其他研究以及全球经济衰退对未来研究资金的潜在影响。协作和网络化研究以及简化的研究流程和远程技术的使用,一直是全球临床医生和科学家努力的核心,对于降低 COVID-19 的发病率和死亡率至关重要。影响:保持研究治理和数据共享的精简高效方法,以促进高质量的协作研究。确保尽早将儿童纳入影响所有年龄段疾病的治疗方法试验中。儿科研究学会应协调有效的流程,以确定关键研究问题,并为婴儿、儿童和青少年的诊断、治疗和预防策略制定跨国临床试验。