Which is better, HLA-matched sibling or haploidentical transplantation?
作者信息
Zheng Xiaodong, Tian Zhigang
机构信息
Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China.
Institue of Immunology, University of Science and Technology of China, Hefei, China.
出版信息
Cell Mol Immunol. 2021 May;18(5):1347. doi: 10.1038/s41423-021-00640-9. Epub 2021 Apr 20.
Abstract
摘要
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Which is better, HLA-matched sibling or haploidentical transplantation?人类白细胞抗原（HLA）匹配的同胞移植和单倍体相合移植，哪种更好？
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Dynamic immune profiling identifies the stronger graft-versus-leukemia (GVL) effects with haploidentical allografts compared to HLA-matched stem cell transplantation.动态免疫分析显示，与 HLA 匹配的干细胞移植相比，半相合同种异体移植具有更强的移植物抗白血病（GVL）效应。
Cell Mol Immunol. 2021 May;18(5):1172-1185. doi: 10.1038/s41423-020-00597-1. Epub 2021 Jan 6.
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Bone Marrow Transplant. 2019 Aug;54(Suppl 2):733-737. doi: 10.1038/s41409-019-0595-0.
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NK cell reconstitution following unmanipulated HLA-mismatched/haploidentical transplantation compared with matched sibling transplantation.与匹配的同胞移植相比，非处理的HLA不匹配/单倍体相同移植后的自然杀伤细胞重建。
Sci China Life Sci. 2020 May;63(5):781-784. doi: 10.1007/s11427-018-9565-5. Epub 2019 Jun 14.
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HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide.采用非清髓性预处理及大剂量移植后环磷酰胺的HLA单倍型相合骨髓移植治疗血液系统恶性肿瘤
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Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation.预处理包括抗胸腺细胞球蛋白，随后进行未处理的HLA配型不合/单倍型相合的血液和骨髓移植，其疗效可与HLA全相合的同胞移植相媲美。
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Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse.完全单倍型不匹配造血干细胞移植：一项针对急性白血病高复发风险患者的II期研究。
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Graft-versus-leukemia reactions in allogeneic chimeras.异基因嵌合体中的移植物抗白血病反应。
Blood. 2004 Feb 1;103(3):767-76. doi: 10.1182/blood-2003-02-0342. Epub 2003 Sep 4.
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