Himmel Nathaniel J, Letcher Jamin M, Cox Daniel N
Neuroscience Institute, Georgia State University, Atlanta, GA 30303.
J Undergrad Neurosci Educ. 2020 Dec 31;19(1):A21-A29. eCollection 2020 Fall.
Herein we discuss a Course-Based Undergraduate Research Experience (CURE) developed in order to engage novice undergraduates in active learning and discovery-driven original research. This course leverages the powerful genetic toolkits available for in order to investigate the cellular and molecular bases of cold nociception. Given the relatively inexpensive nature of rearing, a growing suite of publicly available neurogenomic data, large collections of transgenic stocks available through community stock centers, and 's highly stereotyped behaviors, this CURE design constitutes a cost-effective approach to introduce students to principles and techniques in genetics, genomics, behavioral neuroscience, research design, and scientific presentation. Moreover, we discuss how this paradigm might be adapted for continued use in investigating any number of systems and/or behaviors - a property we posit is key to impactful CURE design.
在此，我们讨论一种基于课程的本科研究体验（CURE），其目的是让本科新生参与主动学习和发现驱动的原创研究。本课程利用现有的强大基因工具包来研究冷痛觉的细胞和分子基础。鉴于饲养成本相对较低、越来越多的公开可用神经基因组数据、通过社区种群中心可获得的大量转基因品系以及[具体动物名称]高度刻板的行为，这种CURE设计构成了一种经济高效的方法，可向学生介绍遗传学、基因组学、行为神经科学、研究设计和科学展示方面的原理和技术。此外，我们讨论了这种范式如何可能被调整以继续用于研究任意数量的系统和/或行为——我们认为这一特性是有影响力的CURE设计的关键。
