Samadi Behrad, Lundstrom Mats, Zetterberg Madeleine, Nilsson Ingela, Montan Per, Behndig Anders, Kugelberg Maria
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
Department of Clinical Sciences, Ophthalmology, Faculty of Medicine, Lund University, Karlskrona, Sweden.
BMJ Open Ophthalmol. 2021 Mar 23;6(1):e000635. doi: 10.1136/bmjophth-2020-000635. eCollection 2021.
To investigate changes in the prescribing patterns of postoperative eye drops following cataract surgery in Sweden from 2010 to 2017.
Data from cataract procedures registered in the National Cataract Register during the month of March from 2010 to 2017 were record linked and sent to the Swedish Prescribed Drug Register, which allowed us to determine which eye drops the patients had obtained from 3 months presurgery to 2 weeks post surgery.
During the 8-year study period, 54 889 surgeries were registered. Combination treatment with steroid and non-steroidal anti-inflammatory drug (NSAID) eye drops increased from 12% in 2010 to 60% in 2017 (p<0.001) while monotherapy with steroids decreased from 71% in 2010 to 26% in 2017 (p<0.001). Monotherapy with NSAIDs after surgery was fairly stable, at 17% in 2010 and 13% in 2017 (p<0.001). Combination treatment was more frequent in patients with diabetic retinopathy (p<0.001) or age-related macular degeneration (p<0.001), while monotherapy with steroids was more frequent in patients with glaucoma (p<0.001). The proportion of monotherapy or combination therapy varied widely between ophthalmic clinics. The prescription of antibiotic eye drops after surgery also varied greatly between clinics, from 0% to 63%, with a national average of 4.9%.
There is a change in the prescription pattern of anti-inflammatory eye drops after cataract surgery in Sweden, with less monotherapy and an increasing proportion of patients receiving a combination of steroid and NSAID eye drops.
调查2010年至2017年瑞典白内障手术后眼药水处方模式的变化。
记录并关联2010年至2017年3月期间在国家白内障登记处登记的白内障手术数据，并将其发送至瑞典处方药登记处，这使我们能够确定患者在术前3个月至术后2周获得了哪些眼药水。
在8年的研究期间，共登记了54889例手术。类固醇与非甾体抗炎药（NSAID）眼药水联合治疗从2010年的12%增至2017年的60%（p<0.001），而类固醇单药治疗从2010年的71%降至2017年的26%（p<0.001）。术后NSAID单药治疗相当稳定，2010年为17%，2017年为13%（p<0.001）。糖尿病性视网膜病变患者（p<0.001）或年龄相关性黄斑变性患者（p<0.001）采用联合治疗更为频繁，而青光眼患者（p<0.001）采用类固醇单药治疗更为频繁。单药治疗或联合治疗的比例在眼科诊所之间差异很大。术后抗生素眼药水的处方在各诊所之间也有很大差异，从0%至63%不等，全国平均为4.9%。
瑞典白内障手术后抗炎眼药水的处方模式发生了变化，单药治疗减少，接受类固醇和NSAID眼药水联合治疗的患者比例增加。
