Wei Peng-Peng, Hunter Sharon K, Ross Randal G
Division of Child and Adolescent Psychiatry, Department of Psychiatry, University of Colorado School of Medicine, Pediatric Mental Health Institute, Children's Hospital Colorado. Dr Wei is currently at New York Presbyterian Hospital, New York, New York. Dr Hunter is currently residing in Houston, TX.
Colo J Psychiatry Psychol. 2017 Jan;2(1):75-83.
Sleep spindles and P50 sensory gating are both reflective of cerebral inhibition, however, are differentially active during different phases of sleep. Assessing whether sleep spindles and P50 sensory gating correlate is a first step to evaluate whether these 2 forms of cerebral inhibition reflect overlapping neural circuits.
EEG data were collected between midnight and 6:00 AM on 13 healthy preschool-aged children. P50 sensory gating, calculated during REM sleep, negatively correlated with spindle duration (r=-.715, p=.006) and inter-peak density (r=.744, p=.004). There was a trend toward higher S2/S1 ratios being associated with fewer peaks per spindle (r=-.546, p=.053). In 4-year-olds, 2 established physiological measures of sensory gating and are correlated despite being maximally active during different stages of sleep.
These results suggest there is an overlap in brain mechanisms underlying each gating mechanism.
睡眠纺锤波和P50感觉门控均反映大脑抑制作用，然而，在睡眠的不同阶段其活跃程度有所不同。评估睡眠纺锤波与P50感觉门控是否相关，是评估这两种大脑抑制形式是否反映重叠神经回路的第一步。
收集了13名健康学龄前儿童在午夜至凌晨6点之间的脑电图数据。在快速眼动睡眠期间计算得出的P50感觉门控与纺锤波持续时间呈负相关（r = -0.715，p = 0.006），与峰间密度呈负相关（r = 0.744，p = 0.004）。S2/S1比值越高，每个纺锤波的峰值越少，不过这一趋势未达到统计学显著水平（r = -0.546，p = 0.053）。在4岁儿童中，两种既定的感觉门控生理指标虽在睡眠的不同阶段达到最大活跃程度，但仍具有相关性。
这些结果表明，每种门控机制背后的大脑机制存在重叠。
