State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, University of Science and Technology of China, Changchun, 130022, China.
College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Instrumental Analysis Center of Qingdao University, Qingdao University, Qingdao, 266071, China.
Angew Chem Int Ed Engl. 2021 Jul 19;60(30):16641-16648. doi: 10.1002/anie.202105206. Epub 2021 Jun 15.
Tumor hypoxia severely limits the therapeutic effects of photodynamic therapy (PDT). Although many methods for oxygen generation exist, substantial safety concerns, spatiotenporal uncontrollability, limited efficacy, and complicated procedures have compromised their practical application. Here, we demonstrate a biocompatiable all-in-one organic semiconductor to provide a photoxidation catalysis mechanism of action. A facile method is developed to produce gram-level C N nanoparticles (NPs)-based organic semiconductor. Under 650 nm laser irradiation, the semiconductor split water to generate O and simultaneously produce singlet oxygen ( O ), showing that the photocatalyst for O evolution and the photosensitizer (PS) for O generation could be synchronously achieved in one organic semiconductor. The inherent nucleus targeting capacity endows it with direct and efficient DNA photocleavage. These findings pave the way for developing organic semiconductor-based cancer therapeutic agents.
肿瘤缺氧严重限制了光动力疗法（PDT）的治疗效果。虽然有许多产生氧气的方法，但由于安全性问题严重、时空可控性差、疗效有限以及操作复杂，这些方法的实际应用受到了限制。在这里，我们展示了一种生物相容性的全有机半导体，提供了一种光氧化催化作用机制。我们开发了一种简单的方法来制备基于 C N 纳米颗粒（NPs）的有机半导体。在 650nm 激光照射下，半导体将水分解生成 O 和单线态氧（ O ），表明光催化剂可以同时实现 O 的产生和光生剂（PS）的产生。半导体的固有核靶向能力使其具有直接且高效的 DNA 光裂解能力。这些发现为开发基于有机半导体的癌症治疗剂铺平了道路。
