CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Haidian District, Beijing, 100190, China.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences (UCAS), No. 19 Yuquan Rd, Shijingshan District, Beijing, 100049, China.
ChemMedChem. 2021 Aug 19;16(16):2452-2458. doi: 10.1002/cmdc.202100254. Epub 2021 May 18.
Self-assembly peptide materials have promoted the development of science research including life science, optics, medicine, and catalysis over the past two decades. Especially in tumor treatment, peptide self-assembly strategies have exhibited promising potential by their high degree of biocompatibility, construction modularization, and diversity in structure controllability. Driven by physical and chemical triggers, peptides can self-assemble in vivo to form fibers, spheres, hydrogels, or ribbons to achieve predeterminate biological functions. Peptide self-assembly triggered by chemical reactions provides superior specificity and intelligent responsiveness to produce assembly-induced biological effects in target regions. Herein, from the perspective of triggers of peptide assembly, we briefly review the applications of in vivo peptide self-assembly strategies for tumor treatment, including tumor-pathology-factor-induced chemical reactions and bio-orthogonal reactions.
在过去的二十年中，自组装肽材料促进了生命科学、光学、医学和催化等多个科学领域的发展。特别是在肿瘤治疗方面，肽自组装策略因其高度的生物相容性、构建的模块化以及结构可控性的多样性，显示出了广阔的应用前景。在物理和化学触发因素的驱动下，肽可以在体内自组装成纤维、球体、水凝胶或带状物，从而实现预定的生物学功能。由化学反应触发的肽自组装为在目标区域产生组装诱导的生物学效应提供了卓越的特异性和智能响应性。在此，我们从肽组装的触发因素的角度，简要综述了用于肿瘤治疗的体内肽自组装策略的应用，包括肿瘤-病理因子诱导的化学反应和生物正交反应。
