Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, International Joint Research Laboratory for Lipid Nutrition and Safety, National Engineering Research Center for Functional Food, School of Food Science and Technology, Jiangnan, University, Wuxi 214122, China.
College of Food Science and Engineering, Yangzhou University, 225127 Yangzhou, Jiangsu Province, China.
J Agric Food Chem. 2021 May 12;69(18):5405-5415. doi: 10.1021/acs.jafc.1c00013. Epub 2021 Apr 21.
There is great interest in the application of a lipid-based delivery system (like nanoemulsion) to improve the bioavailability of lipophilic components. Although emulsion characteristics are believed to be influenced by oil types, there is still a lack of systematic research concentrating on the effect of oil saturation degree on the nanoemulsion quality, especially for evaluation of the bioactivity. Here, we aimed to test the effect of oil saturation degree on the physical stability, oxidative stability, and bioactivity of the designed nanoemulision system. Our findings suggest that the oxidative stability and bioactivity of a nanoemulsion incorporating tocopherol and sesamol highly depend on the oil saturation. A nanoemulsion with an oil with a high degree of unsaturation was more susceptible to oxidation, and addition of tocopherol and sesamol could retard the lipid oxidation. Sesamol exhibited better bioactivity during the experiment compared with tocopherol in the () model. The lipid-lowering effect of tocopherol and sesamol increased with lower saturation oil groups. The antioxidant activity of tocopherol and sesamol was higher in the high saturation oil groups. Overall, the obtained data is meaningful for applications using the designed systems to deliver lipophilic ingredients.
人们对应用基于脂质的递药系统（如纳米乳）来提高亲脂性成分的生物利用度很感兴趣。虽然乳剂特性被认为受到油类的影响，但仍缺乏集中研究油饱和度对纳米乳质量影响的系统研究，特别是对于生物活性的评估。在这里，我们旨在测试油饱和度对设计的纳米乳系统的物理稳定性、氧化稳定性和生物活性的影响。我们的研究结果表明，含有生育酚和芝麻酚的纳米乳的氧化稳定性和生物活性高度依赖于油的饱和度。不饱和程度高的油制成的纳米乳更容易氧化，添加生育酚和芝麻酚可以延缓脂质氧化。芝麻酚在（）模型中的生物活性优于生育酚。生育酚和芝麻酚的降血脂作用随油饱和度降低的油组增加。生育酚和芝麻酚在高饱和度油组中的抗氧化活性更高。总的来说，这些数据对于使用设计的系统来传递亲脂性成分的应用具有重要意义。
