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本文引用的文献

1
The pathophysiology of 'happy' hypoxemia in COVID-19.新型冠状病毒肺炎“快乐”低氧血症的病理生理学。
Respir Res. 2020 Jul 28;21(1):198. doi: 10.1186/s12931-020-01462-5.
2
Hypoglycemic cardiac arrest and rapid return-of-spontaneous circulation (ROSC) with dextrose.低血糖性心搏骤停和葡萄糖快速自主循环恢复(ROSC)。
Am J Emerg Med. 2020 Sep;38(9):1981.e1-1981.e3. doi: 10.1016/j.ajem.2020.05.025. Epub 2020 May 19.
3
Prognostic value of lactate in prehospital care as a predictor of early mortality.院前急救中乳酸对早期死亡率预测的预后价值。
Am J Emerg Med. 2019 Sep;37(9):1627-1632. doi: 10.1016/j.ajem.2018.11.028. Epub 2018 Nov 19.
4
Endocrine Emergencies With Neurologic Manifestations.伴有神经表现的内分泌急症
Continuum (Minneap Minn). 2017 Jun;23(3, Neurology of Systemic Disease):778-801. doi: 10.1212/CON.0000000000000467.
5
Continuous glucose monitoring for patients with type 1 diabetes and impaired awareness of hypoglycaemia (IN CONTROL): a randomised, open-label, crossover trial.1 型糖尿病且低血糖感知受损患者的连续血糖监测(IN CONTROL):一项随机、开放标签、交叉试验。
Lancet Diabetes Endocrinol. 2016 Nov;4(11):893-902. doi: 10.1016/S2213-8587(16)30193-0. Epub 2016 Sep 15.
6
Diabetic emergencies - ketoacidosis, hyperglycaemic hyperosmolar state and hypoglycaemia.糖尿病急症——酮症酸中毒、高血糖高渗状态和低血糖。
Nat Rev Endocrinol. 2016 Apr;12(4):222-32. doi: 10.1038/nrendo.2016.15. Epub 2016 Feb 19.
7
Mechanisms of hypoglycemia unawareness and implications in diabetic patients.低血糖感知缺失的机制及其对糖尿病患者的影响。
World J Diabetes. 2015 Jul 10;6(7):912-26. doi: 10.4239/wjd.v6.i7.912.
8
Lactic acidosis.乳酸性酸中毒
N Engl J Med. 2014 Dec 11;371(24):2309-19. doi: 10.1056/NEJMra1309483.
9
"Hyper-warburgism," a cause of asymptomatic hypoglycemia with lactic acidosis in a patient with non-Hodgkin's lymphoma.“高 Warburg 效应”导致非霍奇金淋巴瘤患者无症状性低血糖伴乳酸性酸中毒
J Clin Endocrinol Metab. 2012 Dec;97(12):4311-6. doi: 10.1210/jc.2012-2327. Epub 2012 Oct 9.
10
Lactate/pyruvate ratio as a marker of tissue hypoxia in circulatory and septic shock.乳酸/丙酮酸比值作为循环性休克和脓毒性休克中组织缺氧的标志物。
Anaesth Intensive Care. 2012 May;40(3):427-32. doi: 10.1177/0310057X1204000307.

“快乐”低血糖症的病理生理学。

The pathophysiology of "happy" hypoglycemia.

作者信息

Loeb Thomas, Ozguler Anna, Baer Geraldine, Baer Michel

机构信息

SAMU des Hauts-de-Seine, Assistance Publique - Hôpitaux de Paris, Raymond Poincaré Hospital, University of Paris-Saclay, 104 boulevard Raymond Poincaré, 92 380, Garches, France.

Department of Emergency Medicine, Corporal Michael J. Crescenz VA Medical Center, University of Pennsylvania Medical Center, Philadelphia, PA, USA.

出版信息

Int J Emerg Med. 2021 Apr 21;14(1):23. doi: 10.1186/s12245-021-00348-7.

DOI:10.1186/s12245-021-00348-7
PMID:33882828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8058752/
Abstract

BACKGROUND

Hypoglycemia usually includes various neurological symptoms, which are the consequence of neuroglycopenia. When it is severe, it is associated with altered mental status, even coma.

CASE PRESENTATION

We report the case of a patient with severe hypoglycemia, completely asymptomatic, due to the increase of lactate production in response to tissue hypoperfusion following a hemorrhagic shock. This illustrates that lactate can substitute glucose as an energy substrate for the brain. It is also a reminder that this metabolite, despite its bad reputation maintained by its role as a marker of severity in critical care patients, has a fundamental role in our metabolism.

CONCLUSIONS

Following the example of the "happy hypoxemia" recently reported in the literature describing asymptomatic hypoxemia in COVID-19 patients, we describe a case of "happy hypoglycemia."

摘要

背景

低血糖通常包括各种神经症状,这是神经低血糖症的后果。严重时,它与精神状态改变甚至昏迷有关。

病例报告

我们报告一例严重低血糖患者,该患者完全无症状,其病因是出血性休克后组织灌注不足导致乳酸生成增加。这表明乳酸可以替代葡萄糖作为大脑的能量底物。这也提醒我们,尽管这种代谢物因其在重症患者中作为严重程度标志物的作用而声名不佳,但它在我们的新陈代谢中具有重要作用。

结论

以最近文献中报道的描述COVID-19患者无症状低氧血症的“快乐低氧血症”为例,我们描述了一例“快乐低血糖症”。