华法林诱导性皮肤坏死：一种罕见病症。

Warfarin-induced skin necrosis: a rare condition.

机构信息

Department of Surgery, University of Ghana Medical School, Accra, Ghana.

Department of Medicine, Korle Bu Teaching Hospital, Accra, Ghana.

出版信息

Ghana Med J. 2020 Dec;54(4):269-273. doi: 10.4314/gmj.v54i4.10.

DOI:10.4314/gmj.v54i4.10

PMID:33883776

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8042803/

Abstract

UNLABELLED

Warfarin induced skin necrosis is a rare debilitating and, in some cases, life-threatening complication. A 47-year-old male on life-long anticoagulation omits his medication and develops extensive skin necrosis of the left leg complicated by acute renal failure three days after restarting warfarin. Investigations reveal possible Protein S deficiency which is known to be a predisposing condition. Various mechanisms have been proposed as the underlying cause. He was managed on heparin, wound debridement and skin grafting. Warfarin was restarted concurrently with heparin. Knowledge of this complication will enable timely diagnosis and treatment.

FUNDING

None declared.

摘要

背景：华法林诱导性皮肤坏死是一种罕见的、使人虚弱的并发症，在某些情况下甚至会危及生命。一名 47 岁男性因终身抗凝而漏用药物，在重新开始使用华法林三天后，左腿出现广泛皮肤坏死，并伴有急性肾衰竭。检查显示可能存在蛋白 S 缺乏，这是一种已知的易患疾病。已有多种机制被提出作为潜在的病因。他接受了肝素、伤口清创和植皮治疗。同时，华法林也与肝素一起重新开始使用。了解这种并发症将有助于及时诊断和治疗。

结论：未发现资金来源。