Adugna Biyansa, Tarekegn Zewdu Seyoum, Damtie Debasu, Woldegebreal Seleshe Nigatu, Raju R P, Maru Moges, Ayele Abrham
College of Veterinary Medicine, Semera University, Semera, Ethiopia.
Department of Veterinary Paraclinical Studies, College of Veterinary Medicine and Animal Sciences, University of Gondar, Gondar, Ethiopia.
Infect Drug Resist. 2021 Apr 12;14:1295-1303. doi: 10.2147/IDR.S299106. eCollection 2021.
Toxoplasmosis is a life-threatening disease in pregnant women, having social and economic impacts due to congenital toxoplasmosis. However, in Ethiopia, it is neglected zoonotic disease, which requires screening and identifying risk factors in pregnant women to plan a public health intervention.
This institutional-based cross-sectional study was employed from March to April 2019 to estimate the seropositivity and assess potential risk factors for among pregnant women attending antenatal care in four public hospitals in Northwest Ethiopia. Four hundred and one pregnant women were recruited to collect serum samples. antibodies were tested using Toxo-Latex slide agglutination test.
Thus, the overall seropositivity for was found 70.8% (95% CI: 66.3-75.5). Multivariable logistic regression analysis showed that the average monthly income, occupational status, habits of handwashing practices after handling raw meat, water sources for drinking and agroclimatic situations revealed significant ( < 0.05) effects on seropositivity for in pregnant women.
This survey showed high seropositivity for among pregnant women in Northwest Ethiopia. Therefore, further studies on bioassay, isolation and genotype of the pathogen are crucial. It also requires action to prevent and control the infection with in pregnant women, which poses a potential threat to a foetus.
弓形虫病对孕妇来说是一种危及生命的疾病，由于先天性弓形虫病会产生社会和经济影响。然而，在埃塞俄比亚，它是一种被忽视的人畜共患病，需要对孕妇进行筛查并确定风险因素，以便规划公共卫生干预措施。
本基于机构的横断面研究于2019年3月至4月开展，旨在估计埃塞俄比亚西北部四家公立医院接受产前护理的孕妇中弓形虫的血清阳性率，并评估其潜在风险因素。招募了401名孕妇以采集血清样本。使用弓形虫乳胶凝集试验检测弓形虫抗体。
因此，弓形虫的总体血清阳性率为70.8%（95%置信区间：66.3 - 75.5）。多变量逻辑回归分析表明，平均月收入、职业状况、处理生肉后洗手习惯、饮用水水源和农业气候状况对孕妇弓形虫血清阳性率有显著（P < 0.05）影响。
本次调查显示埃塞俄比亚西北部孕妇中弓形虫血清阳性率较高。因此，对该病原体的生物测定、分离和基因型进行进一步研究至关重要。还需要采取行动预防和控制孕妇感染弓形虫，因为这对胎儿构成潜在威胁。
