Van Meulenbroek Thijs, Conijn Arnoud E A, Huijnen Ivan P J, Engelbert Raoul H H, Verbunt Jeanine A
Department of Rehabilitation Medicine, Research School CAPHRI, Maastricht University, Maastricht, The Netherlands.
Adelante, Centre of Expertise in Rehabilitation and Audiology, Hoensbroek, The Netherlands.
J Rehabil Med Clin Commun. 2020 May 8;3:1000033. doi: 10.2340/20030711-1000033. eCollection 2020.
To determine whether adolescents with generalized hypermobility spectrum disorder/ hypermobile Ehlers-Danlos syndrome (G-HSD/ hEDS) show changes in the level of disability, physical functioning, perceived harmfulness and pain intensity after completing multidisciplinary rehabilitation treatment.
Pre-test post-test design. Fourteen adolescents with G-HSD/hEDS participated. The multidisciplinary rehabilitation treatment consisted of a combination of physical training and exposure . Physical training aims to improve aerobic capacity, muscle strength and propriocepsis for compensating hypermobility. Exposure aims to decrease disability and pain-related fear. Pre- and post-treatment assessments were conducted to assess the level of disability, physical functioning (motor performance, muscle strength and physical activity level), perceived harmfulness and pain intensity.
After completing multidisciplinary rehabilitation treatment, the adolescents showed a significant and clinically relevant improvement (improvement of 67%, <0.01) in functional disability. Furthermore, significant improvements were found in motor performance ( < 0.01), muscle strength ( < 0.05), perceived harmfulness ( < 0.01) and pain intensity ( <0.01) after completing multidisciplinary rehabilitation treatment.
Multidisciplinary rehabilitation treatment leads to a significantly and clinically relevant improvement in the level of disability for adolescents with G-HSD/hEDS. Positive effects were also found in physical functioning, perceived harmfulness and pain intensity. Although the results of this multidisciplinary rehabilitation treatment for adolescents with G-HSD/hEDS are promising, further study is needed to confirm these findings in a randomized design.
确定患有广泛性关节活动过度谱系障碍/活动过度型埃勒斯-当洛综合征（G-HSD/hEDS）的青少年在完成多学科康复治疗后，其残疾水平、身体功能、感知到的伤害性和疼痛强度是否会发生变化。
采用前后测设计。14名患有G-HSD/hEDS的青少年参与了研究。多学科康复治疗包括体育训练和暴露疗法相结合。体育训练旨在提高有氧能力、肌肉力量和本体感觉，以补偿关节活动过度。暴露疗法旨在减少残疾和与疼痛相关的恐惧。在治疗前后进行评估，以评估残疾水平、身体功能（运动表现、肌肉力量和身体活动水平）、感知到的伤害性和疼痛强度。
完成多学科康复治疗后，青少年的功能残疾有显著且具有临床意义的改善（改善了67%，<0.01）。此外，完成多学科康复治疗后，在运动表现（<0.01）、肌肉力量（<0.05）、感知到的伤害性（<0.01）和疼痛强度（<0.01）方面也发现了显著改善。
多学科康复治疗可使患有G-HSD/hEDS的青少年的残疾水平得到显著且具有临床意义的改善。在身体功能、感知到的伤害性和疼痛强度方面也发现了积极效果。尽管这种针对患有G-HSD/hEDS青少年的多学科康复治疗结果很有前景，但仍需要进一步研究以随机设计来证实这些发现。
