中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值与严重创伤早期住院病死率的相关性。

Association of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with in-hospital mortality in the early phase of severe trauma.

机构信息

Department of Emergency Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju-South Korea.

Department of Emergency Medical Technology, Namseoul University, Chungnam-South Korea.

出版信息

Ulus Travma Acil Cerrahi Derg. 2021 May;27(3):290-295. doi: 10.14744/tjtes.2020.02516.

DOI:10.14744/tjtes.2020.02516

PMID:33884592

Abstract

BACKGROUND

This study aimed to examine the relationship between the immediate and early complete blood count-based scores and prognosis in trauma patients.

METHODS

This retrospective observational study included adult patients admitted for severe trauma between January 2014 and December 2018. Multivariate logistic regression analysis was conducted to assess the association between the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR), and in-hospital mortality.

RESULTS

Among the 288 patients included in the study, in-hospital mortality was 26.4% (n=76). Immediately after emergency department (ED) arrival, non-survivors had lower NLR (3.28 vs. 4.73) and PLR (55.73 vs. 87.21) and higher LMR (4.91 vs. 3.91) than survivors. At 6 h after ED arrival, non-survivors had lower NLR (4.98 vs. 8.37) and PLR (58.23 vs. 123.74) and higher LMR (2.88 vs. 1.69) than survivors. Results of multivariate regression analysis revealed that NLR (odds ratio [OR], 0.926; 95% confidence interval [CI], 0.881-0.973) and PLR (OR, 0.994; 95% CI, 0.990-0.998) at 6 h after ED arrival were independently associated with in-hospital mortality.

CONCLUSION

Lower NLR and PLR at 6 h after ED arrival were associated with in-hospital mortality in cases of severe trauma.

摘要

背景

本研究旨在探讨创伤患者即时和早期基于全血细胞计数的评分与预后之间的关系。

方法

本回顾性观察性研究纳入了 2014 年 1 月至 2018 年 12 月期间因严重创伤入院的成年患者。采用多变量逻辑回归分析评估中性粒细胞与淋巴细胞比值（NLR）、淋巴细胞与单核细胞比值（LMR）和血小板与淋巴细胞比值（PLR）与院内死亡率之间的关系。

结果

在纳入的 288 例患者中，院内死亡率为 26.4%（n=76）。在急诊科（ED）到达后即刻，非幸存者的 NLR（3.28 比 4.73）和 PLR（55.73 比 87.21）较低，而 LMR（4.91 比 3.91）较高。在 ED 到达后 6 小时，非幸存者的 NLR（4.98 比 8.37）和 PLR（58.23 比 123.74）较低，而 LMR（2.88 比 1.69）较高。多变量回归分析结果显示，ED 到达后 6 小时 NLR（比值比 [OR]，0.926；95%置信区间 [CI]，0.881-0.973）和 PLR（OR，0.994；95%CI，0.990-0.998）与院内死亡率独立相关。