Sam Miraheal Adadzewa, Hussain Abdulzahra, Pegler Maya Elizabeth, Pearson Emma Jane Bligh, Omar Islam, Boyle Maureen, Singhal Rishi, Mahawar Kamal
Bariatric Unit, Sunderland Royal Hospital, South Tyneside and Sunderland NHS Foundation Trust, UK.
Bariatric unit, Doncaster and Bassetlaw Teaching Hospitals, Doncaster, UK.
J Minim Access Surg. 2022 Jan-Mar;18(1):38-44. doi: 10.4103/jmas.JMAS_249_20.
Some studies have shown that one anastomosis gastric bypass (OAGB) results in the derangement of liver function tests (LFTs). We wanted to study this in our patients.
The aims are to study the effect of OAGB on LFTs and to compare the effect of a biliopancreatic limb (BPL) of 150 cm (OAGB-150) to a BPL of 200 cm (OAGB-200).
The study was a retrospective cohort study conducted at a university hospital.
Information was obtained from our prospectively maintained database and hospital's computerised records.
A P < 0.05 was regarded statistically significant; however, given the number of variables examined, findings should be regarded as exploratory.
A total of 405 patients underwent an OAGB-200 (n = 234) or OAGB-150 (n = 171) in our unit between October 2012 and July 2018. There were significant improvements in gamma-glutamyl transpeptidase (GGT) levels at 1 and 2 years after OAGB-200 and significant worsening in the levels of alkaline phosphatase (ALP) and albumin at 1 and 2 years. There was a significant improvement in GGT levels at 1 and 2 years after OAGB-150 and in alanine transaminase levels at 1 year. There was a significant worsening in ALP and albumin levels at both follow-up points in this group. OAGB-150 group had a significantly lower bilirubin level at 1 year and significantly fewer abnormal ALP values at 2 years in comparison with OAGB-200 patients.
This exploratory study demonstrates the overall safety of OAGB with regard to its effect on LFTs, with no remarkable difference between OAGB-150 and OAGB-200.
一些研究表明，单吻合口胃旁路术（OAGB）会导致肝功能检查（LFTs）紊乱。我们想在我们的患者中研究这一情况。
目的是研究OAGB对LFTs的影响，并比较150厘米胆胰支（BPL）（OAGB - 150）与200厘米BPL（OAGB - 200）的效果。
该研究是在一家大学医院进行的回顾性队列研究。
信息来自我们前瞻性维护的数据库和医院的计算机记录。
P < 0.05被视为具有统计学意义；然而，鉴于所检查的变量数量，研究结果应被视为探索性的。
2012年10月至2018年7月期间，我们科室共有405例患者接受了OAGB - 200（n = 234）或OAGB - 150（n = 171）手术。OAGB - 200术后1年和2年时，γ-谷氨酰转肽酶（GGT）水平有显著改善，碱性磷酸酶（ALP）和白蛋白水平在1年和2年时显著恶化。OAGB - 150术后1年和2年时GGT水平有显著改善，1年时丙氨酸转氨酶水平也有显著改善。该组两个随访点的ALP和白蛋白水平均显著恶化。与OAGB - 200患者相比，OAGB - 150组在1年时胆红素水平显著较低，2年时ALP异常值显著较少。
这项探索性研究证明了OAGB对LFTs影响方面的总体安全性，OAGB - 150和OAGB - 200之间没有显著差异。
