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一名 10 岁女孩患晚期急性淋巴细胞白血病复发,被诊断患有 COVID-19 并接受瑞德西韦治疗。

A 10-Year-old Girl With Late Acute Lymphoblastic Leukemia Recurrence Diagnosed With COVID-19 and Treated With Remdesivir.

机构信息

Department of Pediatrics with Clinical Assessment Unit.

Clinic of Oncology, Child Hematology, Clinical Transplantology and Pediatry, Medical University of Warsaw.

出版信息

J Pediatr Hematol Oncol. 2022 Mar 1;44(2):e537-e538. doi: 10.1097/MPH.0000000000002166.

DOI:10.1097/MPH.0000000000002166
PMID:33885040
Abstract

Patients with hemato-oncologic diseases are particularly vulnerable to severe infections. Adult patients with blood cancers infected with SARS-CoV-2 had poorer treatment outcomes and higher mortality than patients with COVID-19 without burden. However, in pediatric patients with hemato-oncologic diseases the course of COVID-19 is milder than in adults in the same group of patients. In this report, we describe the case of our patient with acute lymphoblastic leukemia infected with SARS-CoV-2 and treated with remdesivir. We also review the existing literature of pediatric patients who have been diagnosed with both hemato-oncologic diseases and COVID-19.

摘要

血液肿瘤疾病患者特别容易受到严重感染。感染 SARS-CoV-2 的血液癌症成年患者的治疗结果比无负担的 COVID-19 患者差,死亡率更高。然而,在患有血液肿瘤疾病的儿科患者中,COVID-19 的病程比同组成年患者轻。在本报告中,我们描述了一例感染 SARS-CoV-2 并接受瑞德西韦治疗的急性淋巴细胞白血病患者。我们还回顾了已诊断出患有血液肿瘤疾病和 COVID-19 的儿科患者的现有文献。

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1
A 10-Year-old Girl With Late Acute Lymphoblastic Leukemia Recurrence Diagnosed With COVID-19 and Treated With Remdesivir.一名 10 岁女孩患晚期急性淋巴细胞白血病复发,被诊断患有 COVID-19 并接受瑞德西韦治疗。
J Pediatr Hematol Oncol. 2022 Mar 1;44(2):e537-e538. doi: 10.1097/MPH.0000000000002166.
2
Management of an Immunocompromised Pediatric Patient With Multiple Hospitalizations for Symptomatic COVID-19.免疫功能低下的儿科患者多次因有症状 COVID-19 住院的管理。
J Pediatr Hematol Oncol. 2022 Jan 1;44(1):e293-e295. doi: 10.1097/MPH.0000000000002014.
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Successful early treatment combining remdesivir with high-titer convalescent plasma among COVID-19-infected hematological patients.瑞德西韦与高滴度康复期血浆联合用于COVID-19感染血液病患者的早期治疗取得成功。
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Remdesivir during induction chemotherapy for newly diagnosed paediatric acute lymphoblastic leukaemia with concomitant SARS-CoV-2 infection.在新诊断的伴有SARS-CoV-2感染的小儿急性淋巴细胞白血病诱导化疗期间使用瑞德西韦。
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Antimicrob Agents Chemother. 2024 Aug 7;68(8):e0085624. doi: 10.1128/aac.00856-24. Epub 2024 Jul 18.

引用本文的文献

1
COVID-19 infection in children with blood cancer: A systematic review.血癌患儿的新冠病毒感染:一项系统综述
Ann Hematol. 2025 Feb;104(2):1203-1230. doi: 10.1007/s00277-024-06057-4. Epub 2024 Nov 5.
2
Challenges in Treating Pediatric Cancer Patients during the COVID-19 Pandemic: Balancing Risks and Care.COVID-19 大流行期间治疗儿科癌症患者的挑战:平衡风险和护理。
Viruses. 2024 Apr 26;16(5):690. doi: 10.3390/v16050690.
3
The Impact of COVID-19 on Pediatric Malignancy Diagnosis and Treatment: Never the Same but Lessons Learned.
新冠疫情对儿童恶性肿瘤诊断与治疗的影响:虽非往昔,但收获经验。
Vaccines (Basel). 2023 Mar 15;11(3):667. doi: 10.3390/vaccines11030667.
4
Remdesivir: the first FDA-approved anti-COVID-19 Treatment for Young Children.瑞德西韦:首个获美国食品药品监督管理局批准用于幼儿的抗新冠病毒治疗药物。
Discoveries (Craiova). 2022 Jun 30;10(2):e151. doi: 10.15190/d.2022.10. eCollection 2022 Apr-Jun.
5
A Case Report for Severe COVID-19 in a 9-Year-Old Child Treated with Remdesivir and Dexamethasone.儿童 COVID-19 病例报告:瑞德西韦和地塞米松治疗 9 岁重症患儿
J Korean Med Sci. 2021 Jul 26;36(29):e203. doi: 10.3346/jkms.2021.36.e203.