Regional Medical Centre, Indian Council of Medical Research, Port Blair, Andaman Nicobar Islands; Department of Public Health Dentistry, Meenakshi Ammal Dental College, Chennai, Tamil Nadu, India.
School of Population and Global Health, The University of Western Australia; Telethon Kids Institute, The University of Western Australia, Northern Entrance, Nedlands, Western, Australia.
J Indian Soc Pedod Prev Dent. 2021 Jan-Mar;39(1):9-15. doi: 10.4103/jisppd.jisppd_23_21.
The objective of the study is to determine the association between nonsyndromic oral clefts (OC) in children and ABO, Rh blood groups, lip, and dermatoglyphic patterns of their unaffected parents.
This case-control study was conducted at a tertiary cleft center in Chennai, India, among 240 individuals comprising 80 units (40 cases and controls, respectively). Each unit (triad) was constituted by a child (0-12 years of age) either born with nonsyndromic OC (cases) or with no diagnosed congenital anomaly (control) and their unaffected parents (mother and father). ABO and Rh blood groups, specific lip print, fingerprint pattern, and palmar asymmetry were recorded for each individual. Strength of association of related factors was assessed by multivariable logistic regression reported as adjusted odds ratios and 95% confidence interval.
A-positive blood group was found to be considerably higher among case mothers (14.39 [1.57-32.27]). A higher odds of OCs were observed among case mothers with whorl lip pattern (1.51 [1.16-3.17]) and radial loop pattern in fingers (1.44 [1.09-2.31]) relative to controls. In addition, palmar asymmetry was distinctively higher among case parents compared to controls (P < 0.01).
Findings indicate that A-positive blood group, higher frequency of whorl lip, and radial loop finger patterns in mothers and higher ulnar loop pattern in fathers and palmar asymmetry in both parents increases odds of occurrence of OC among their offspring. These identifiable traits offer potential scope for better service planning among resource-constrained disadvantaged communities in India.
本研究旨在探讨儿童非综合征性口腔裂（OC）与 ABO、Rh 血型、唇和皮肤纹理模式之间的关联。
本病例对照研究在印度钦奈的一家三级腭裂中心进行，共纳入 240 名个体，包括 80 个单位（40 例病例和对照组）。每个单位（三联体）由一名 0-12 岁的儿童组成，要么患有非综合征性 OC（病例），要么没有诊断出先天性异常（对照），以及他们未受影响的父母（母亲和父亲）。记录了每个个体的 ABO 和 Rh 血型、特定唇纹、指纹模式和手掌不对称情况。通过多变量逻辑回归评估相关因素的关联强度，报告为调整后的优势比和 95%置信区间。
发现病例母亲的 A 阳性血型明显较高（14.39 [1.57-32.27]）。与对照组相比，具有涡纹唇模式（1.51 [1.16-3.17]）和手指出现桡侧环纹模式（1.44 [1.09-2.31]）的病例母亲发生 OC 的几率更高。此外，与对照组相比，病例父母的手掌不对称明显更高（P < 0.01）。
研究结果表明，母亲的 A 阳性血型、更高频率的涡纹唇和桡侧环纹手指模式以及父亲的更高频率的尺侧环纹模式和父母双方的手掌不对称都增加了其后代发生 OC 的几率。这些可识别的特征为印度资源有限的弱势社区提供了更好的服务规划潜力。
