Department of Orthopedics, The First Affiliated Hospital of Jinzhou Medical University, 40 Songpo Road, Jinzhou, China 121001, China.
Nanoscale. 2021 Apr 7;13(13):6531-6537. doi: 10.1039/d0nr07176e. Epub 2021 Mar 25.
The wound healing process involves multiple steps including hemostasis, inflammation, proliferation, and tissue remodeling. Nanomaterials have been employed externally for healing wounds. However, their use as systemic therapeutics has not been extensively explored. We report the use of ultra-small noble metal nanoclusters (NCs) for the treatment of skin wounds. Both in vitro and in vivo studies indicate NCs have comprehensive therapeutic effects for wound healing, promoting cell proliferation and migration while decreasing inflammation.
创伤愈合过程涉及多个步骤,包括止血、炎症、增殖和组织重塑。纳米材料已被用于外部伤口愈合。然而,作为全身治疗剂的应用尚未得到广泛探索。我们报告了使用超小贵金属纳米团簇 (NCs) 治疗皮肤伤口。体外和体内研究均表明 NCs 对伤口愈合具有全面的治疗效果,促进细胞增殖和迁移,同时减少炎症。