在埃塞俄比亚的成年 HIV 患者中，咨询、抗逆转录病毒治疗和关系对向性伴侣透露 HIV 阳性状况的影响：系统评价和荟萃分析。
The effect of counseling, antiretroviral therapy and relationship on disclosing HIV positive status to sexual partner among adult HIV patients in Ethiopia: A systematic review and meta-analysis.
机构信息
Department of Reproductive and Family Health, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
出版信息
PLoS One. 2021 Apr 22;16(4):e0249887. doi: 10.1371/journal.pone.0249887. eCollection 2021.
BACKGROUND
Human Immunodeficiency Virus (HIV) is continued as a major public health problem, especially in developing countries. Therefore, this study aimed to estimate the effect of counseling, antiretroviral therapy (ART) and relationship on disclosing HIV positive status to sexual partner among adult HIV patients in Ethiopia.
METHODS
The Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) was used during this review. The study included both published and unpublished studies which were conducted in Ethiopia until the end of 2019. Different electronic databases (PubMed, Cochrane library, CINAHL, Global Health, HINARI and Google scholar) were searched. Data were extracted in Microsoft Excel sheet and STATA/SE 14 was used to meta-analysis. I2 and Egger test statistics were used to test heterogeneity and publication bias respectively.
RESULTS
Twenty-two articles with 8,873 adult HIV infected peoples were included in this systematic review and meta-analysis. The pooled magnitude of disclosing HIV status to sexual partner was 74.63% [95% CI: (67.79, 81.47)]. Counseled [AOR = 4.96, 95% CI: (2.87, 8.55)], ART initiated [AOR = 4.78, 95% CI: (3.84, 5.94)] and who had a smooth relationship before HIV testing [AOR = 6.82, 95% CI: (3.49, 13.33)] were significantly associated with disclosing HIV status to sexual partner.
CONCLUSIONS
Disclosing HIV positive status to sexual partner in Ethiopia was low as the government invested in partner notification. Counseling, ART initiation and smooth relationship before HIV testing were significantly associated with disclosing HIV status to sexual partner. The government needs to strengthen pre and post HIV test counseling even after treatment started to increase disclosing status.
REGISTRATION
The protocol of this systematic review and meta-analysis was registered in the PROSPERO with a specific registration number: CRD42020161276; https://clinicaltrials.gov/.
背景
人类免疫缺陷病毒（HIV）仍然是一个主要的公共卫生问题，特别是在发展中国家。因此，本研究旨在评估咨询、抗逆转录病毒治疗（ART）和关系对埃塞俄比亚成年 HIV 患者向性伴侣披露 HIV 阳性状态的影响。
方法
本综述采用系统评价和荟萃分析的首选报告项目（PRISMA）。该研究包括 2019 年底前在埃塞俄比亚进行的已发表和未发表的研究。使用了不同的电子数据库（PubMed、Cochrane 图书馆、CINAHL、全球健康、HINARI 和 Google Scholar）进行搜索。数据在 Microsoft Excel 工作表中提取，使用 STATA/SE 14 进行荟萃分析。使用 I2 和 Egger 检验统计量分别测试异质性和发表偏倚。
结果
本系统评价和荟萃分析共纳入 22 篇文章，涉及 8873 名成年 HIV 感染者。向性伴侣披露 HIV 状态的综合比例为 74.63%[95%CI：（67.79,81.47）]。接受咨询[AOR=4.96,95%CI：（2.87,8.55）]、开始接受 ART[AOR=4.78,95%CI：（3.84,5.94）]和在 HIV 检测前关系顺利[AOR=6.82,95%CI：（3.49,13.33）]与向性伴侣披露 HIV 状态显著相关。
结论
埃塞俄比亚向性伴侣披露 HIV 阳性状态的比例较低，因为政府投资于伴侣通知。咨询、ART 启动和 HIV 检测前的顺利关系与向性伴侣披露 HIV 状态显著相关。政府需要在开始治疗后加强 HIV 检测前后的咨询，以提高披露率。
注册
本系统评价和荟萃分析的方案已在 PROSPERO 中注册，注册号为：CRD42020161276；https://clinicaltrials.gov/。
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