Elitary Research Centre of Individualised Medicine in Arterial Disease (CIMA), Odense University Hospital, Odense, Denmark.
Department of Cardiac, Thoracic and Vascular Surgery, Odense University Hospital, Odense C, Denmark.
Basic Clin Pharmacol Toxicol. 2021 Jul;129(1):44-51. doi: 10.1111/bcpt.13591. Epub 2021 Apr 30.
Fluoroquinolones (FQ) are associated with an increased risk of tendinopathy, including rupture. Our study aimed to investigate whether FQ use triggered the rupture of aortic aneurysms using a self-controlled design. We hypothesised that the use of FQ was associated with aortic rupture shortly after redeemed FQ prescriptions. Using nationwide data sources, we performed a case-crossover study of cases with ruptured aortic aneurysms. From 1996 to 2016, 58 persons presented with rupture of an aortic aneurysm and a redeemed prescription for any FQ within 28 days. 67% were men, and the median age was 77 years. Some 82.9% presented with a ruptured abdominal aneurysm. In our conditional regression, the crude OR for having rupture with a recent FQ redemption was 1.36 (CI 1.00-1.86). After adjusting for potential confounders, the OR was 1.35 (CI 0.98-1.85). Changing the hazard period to FQ redemption within 60 and 90 days, the OR was 2.16 (CI 1.70-2.76) and 2.21 (CI 1.78-2.75), respectively. In conclusion, we demonstrated an association between FQ use within 60 and 90 days and a diagnosis of ruptured aortic aneurysm.
氟喹诺酮类药物（FQ）与腱病风险增加有关，包括破裂。我们的研究旨在使用自我对照设计调查 FQ 使用是否会引发主动脉瘤破裂。我们假设 FQ 使用与 FQ 处方赎回后不久的主动脉破裂有关。我们使用全国性数据源对破裂性主动脉瘤的病例进行了病例交叉研究。1996 年至 2016 年期间，58 名患者出现了主动脉瘤破裂，并在 28 天内开出了任何 FQ 的处方。82.9%的患者为腹主动脉瘤破裂。在我们的条件回归中，最近 FQ 赎回时发生破裂的粗比值比为 1.36（CI 1.00-1.86）。在调整了潜在混杂因素后，比值比为 1.35（CI 0.98-1.85）。将危险期更改为 FQ 赎回后 60 天和 90 天，比值比分别为 2.16（CI 1.70-2.76）和 2.21（CI 1.78-2.75）。总之，我们证明了 FQ 在 60 天和 90 天内的使用与诊断为破裂性主动脉瘤之间存在关联。
