Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian City, Liaoning Province, PR China.
Department of Radiology, Affiliated Hospital of Medical School, University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, PR China.
Acta Radiol. 2022 May;63(5):596-605. doi: 10.1177/02841851211006311. Epub 2021 Apr 22.
Intravoxel incoherent motion imaging (IVIM) can non-invasively evaluate diffusion and microvascular perfusion.
To explore the myocardium microcirculation of a healthy Chinese population by using cardiac magnetic resonance (CMR) IVIM.
A total of 80 healthy volunteers (44 men, 36 women) who underwent 3.0-T CMR examination were enrolled. All participants had cardiac cine imaging and short-axis CMR-IVIM of the left ventricle (LV) using multiple b-values. The consistency of the IVIM parameters was assessed by intraclass correlation coefficient (ICC) and the Bland-Altman test. Spearman correlation analysis was performed between IVIM parameters and age, and body mass index (BMI). The differences of IVIM parameters were analyzed between gender and different ages.
LV end-diastolic volume (EDV), end-systolic volume (ESV), LVmass, cardiac output (CO), and BMI in the male group were higher than those in the female group (<0.05). IVIM parameters had good intra-observer and inter-observer consistency (≥0.75). Bland-Altman analysis also showed good intra-observer and inter-observer consistency. ADC decreased with increasing female age (rs = -0.37; = 0.01), while IVIM parameters had no correlation with BMI regardless of sex. ADC in the female group had a statistical difference between different age groups. The ADC and f in the male group were lower than those in the female group (<0.05); however, there was no statistical difference in ADC between genders.
IVIM parameters in healthy Chinese volunteers provided good consistency. There was a negative correlation between ADC and age in the female group.
体素内不相干运动成像（IVIM）可无创性评估扩散和微血管灌注。
使用心脏磁共振（CMR）IVIM 技术探讨健康中国人群的心肌微循环。
共纳入 80 名健康志愿者（男 44 名，女 36 名），均行 3.0T CMR 检查。所有受检者均行心脏电影成像和左心室（LV）短轴 CMR-IVIM，采用多个 b 值。采用组内相关系数（ICC）和 Bland-Altman 检验评估 IVIM 参数的一致性。采用 Spearman 相关分析 IVIM 参数与年龄、体质量指数（BMI）的相关性。分析不同性别和不同年龄组间 IVIM 参数的差异。
男性组的 LV 舒张末期容积（EDV）、收缩末期容积（ESV）、LV 质量、心输出量（CO）和 BMI 均高于女性组（P<0.05）。IVIM 参数观察者内和观察者间一致性较好（≥0.75）。Bland-Altman 分析也显示观察者内和观察者间一致性较好。ADC 随女性年龄增加而降低（rs=-0.37；P=0.01），而无论性别，IVIM 参数与 BMI 均无相关性。女性组不同年龄组间 ADC 存在统计学差异。男性组的 ADC 和 f 低于女性组（P<0.05），但两性间 ADC 无统计学差异。
健康中国志愿者的 IVIM 参数具有良好的一致性。女性组的 ADC 与年龄呈负相关。
