Course trajectories of anxiety disorders: Results from a 6-year follow-up in a general population study.

OBJECTIVE

Little is known about the course of anxiety disorders in the general population. This study provides insights into the course of anxiety disorders in the general population taking into account transition to residual symptoms and to other diagnostic categories.

METHODS

Using data from three waves of the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2;  = 6646), subjects with anxiety disorders (T = 243) were divided into three mutually exclusive course trajectories according to their diagnostic status at 3-year (T) and 6-year (T) follow-up: remission group (no disorder at T), intermittent course group (no disorder at T and disorder at T) and chronic course group (disorder at all measurements). Transition to residual symptoms or other psychopathology were studied. In addition, predictors of course trajectories were assessed.

RESULTS

During 6-year follow-up, 77.8% of subjects achieved remission, 14.0% followed an intermittent course and 8.2% a chronic course. Of those in remission, residual anxiety symptoms remained in 46.6%, while 7.9% developed another disorder between T and T. Compared with the remitting group, a chronic course was predicted by not living with a partner, multiple negative life events, neuroticism, lower mental functioning, severity of anxiety symptoms, use of mental health care and medication use.

LIMITATIONS

The intermittent and chronic course groups were small, limiting statistical power. As a result, certain predictors may not have reached significance.

CONCLUSIONS

In the general population at 6-year follow-up, 77.8% of subjects with anxiety disorders achieved remission. Because of transition to residual symptoms or another diagnostic category, only 52.4% of those subjects had a true favourable outcome.