Leinweber F J, Szpiech J M, Di Carlo F J
J Pharm Sci. 1978 Jan;67(1):129-31. doi: 10.1002/jps.2600670138.
Urine collected for 24 hr from rats given a single oral dose of 3H-l-bunolol (10 mg/kg) was found to contain only 25.8% of the dose and more than 30 labeled compounds. Nine compounds were identified and quantified as follows: bunolol (0.35% of urinary tritium), bunolol glucuronide (5.12%), bunolol sulfate (0.08%), dihydrobunolol (0.08%), dihydrobunolol glucuronide (0.74%), dihydrobunolol sulfate (0.12%), hydroxydihydrobunolol (0.58%), beta-(5-oxytetralonyl)lactic acid (0.74%), and (5-oxytetralonyl) acetic acid glucuronide (1.12%). The total quantity of identified labeled compounds was only 2.3% of the dose and 8.9% of the urinary radioactivity.
给大鼠单次口服剂量为3H-1-布诺洛尔（10毫克/千克）后，收集其24小时尿液，发现尿液中仅含有25.8%的剂量以及30多种标记化合物。鉴定并定量了9种化合物，具体如下：布诺洛尔（占尿中氚的0.35%）、布诺洛尔葡糖醛酸苷（5.12%）、布诺洛尔硫酸盐（0.08%）、二氢布诺洛尔（0.08%）、二氢布诺洛尔葡糖醛酸苷（0.74%）、二氢布诺洛尔硫酸盐（0.12%）、羟基二氢布诺洛尔（0.58%）、β-（5-氧代四氢萘甲酰基）乳酸（0.74%）以及（5-氧代四氢萘甲酰基）乙酸葡糖醛酸苷（1.12%）。已鉴定的标记化合物总量仅为剂量的2.3%，占尿中放射性的8.9%。
