Buchholz Verena N, Mühle Christiane, Kornhuber Johannes, Lenz Bernd
Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Front Psychiatry. 2021 Apr 6;12:517411. doi: 10.3389/fpsyt.2021.517411. eCollection 2021.
Pornography addiction and sexual dysfunction are increasingly prevalent in young men. Previous studies suggest that prenatal androgen exposure plays a role in addiction and sexual functionality. Here, we tested whether lower second-to-fourth finger length ratio (2D:4D) and later age at spermarche, both putative indicators of higher androgen levels , correlate with online sexual compulsivity (OSC scale of ISST), erectile function (IIEF-5), and ejaculatory control (PEPA) in 4,370 young men (age IQR: 25-26 years) of the Cohort Study on Substance Use Risk Factors. Statistical analyses revealed that lower 2D:4D correlated with higher scores on the OSC scale. Moreover, higher age at spermarche correlated with higher OSC scores and decreased erectile function. Interestingly, OSC severity, but not the frequency of pornography use, correlated negatively with erectile function and ejaculatory control. This is the first study to associate two independent proxies of prenatal testosterone level with OSC. These findings provide novel insight into intrauterine predisposition of sexual behavior and related sexual function in adulthood.
色情成瘾和性功能障碍在年轻男性中越来越普遍。先前的研究表明，产前雄激素暴露在成瘾和性功能方面起作用。在此，我们测试了较低的食指与无名指长度比（2D:4D）以及较晚的首次遗精年龄（均为较高雄激素水平的假定指标）是否与物质使用风险因素队列研究中的4370名年轻男性（年龄四分位距：25 - 26岁）的网络性强迫行为（ISST的OSC量表）、勃起功能（IIEF - 5）和射精控制（PEPA）相关。统计分析显示，较低的2D:4D与OSC量表上的较高得分相关。此外，较晚的首次遗精年龄与较高的OSC得分和勃起功能下降相关。有趣的是，OSC严重程度而非色情使用频率与勃起功能和射精控制呈负相关。这是第一项将产前睾酮水平的两个独立指标与OSC相关联的研究。这些发现为成年期性行为和相关性功能的宫内易感性提供了新的见解。
