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胆汁管型肾病——肾损伤的一个重要胆汁相关病因

Bile Cast Nephropathy an Important Biliary Culprit of Kidney Injury.

作者信息

Yusuf Fouzia, Weissman Simcha, Qureshi Nabeel, Ibrahim Mounir, Kurtz Daniel, Manandhar Lochana, Sciarra Michael, Elias Sameh

机构信息

Department of Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, NJ, USA.

Department of Medicine, NYIT College of Osteopathic Medicine, Old Westbury, NY, USA.

出版信息

J Community Hosp Intern Med Perspect. 2021 Mar 23;11(2):253-255. doi: 10.1080/20009666.2021.1877397.

DOI:10.1080/20009666.2021.1877397
PMID:33889331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8043563/
Abstract

Bile cast nephropathy (BCN) is a rare form of acute kidney injury (AKI) that occurs in the setting of hyperbilirubinemia. We present the case of a 67 year-old male with severe kidney injury who was found to have obstructive cholestasis. By way of this report, we aim to expand upon the existing literature and showcase the importance of timely endoscopic retrograde cholangio-pancreatography (ERCP) in this setting, in order to prevent irreversible kidney damage.

摘要

胆汁管型肾病(BCN)是一种发生于高胆红素血症情况下的罕见急性肾损伤(AKI)形式。我们报告一例67岁男性严重肾损伤患者,该患者被发现存在梗阻性胆汁淤积。通过本报告,我们旨在扩充现有文献,并展示在这种情况下及时进行内镜逆行胰胆管造影(ERCP)的重要性,以防止不可逆转的肾损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd1/8043563/9bd6acc10f50/ZJCH_A_1877397_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd1/8043563/215de4fb4c3d/ZJCH_A_1877397_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd1/8043563/d22cc94a8cef/ZJCH_A_1877397_F0002_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd1/8043563/9bd6acc10f50/ZJCH_A_1877397_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd1/8043563/215de4fb4c3d/ZJCH_A_1877397_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd1/8043563/d22cc94a8cef/ZJCH_A_1877397_F0002_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd1/8043563/9bd6acc10f50/ZJCH_A_1877397_F0003_OC.jpg

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Bile Cast Nephropathy an Important Biliary Culprit of Kidney Injury.胆汁管型肾病——肾损伤的一个重要胆汁相关病因
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Transl Gastroenterol Hepatol. 2025 Apr 10;10:27. doi: 10.21037/tgh-24-98. eCollection 2025.
2
Bile cast nephropathy: A systematic review of case reports and case series.胆汁管型肾病:病例报告和病例系列的系统评价
World J Hepatol. 2025 Apr 27;17(4):105120. doi: 10.4254/wjh.v17.i4.105120.

本文引用的文献

1
Role of inflammation and inflammasome activation in human bile cast nephropathy.炎症和炎症小体激活在人胆汁淤积性铸型肾病中的作用。
Nephrology (Carlton). 2020 Jun;25(6):502-506. doi: 10.1111/nep.13696. Epub 2020 Feb 7.
2
Bile Cast Nephropathy: The Unknown Dangers of Online Shopping.
Case Rep Nephrol Dial. 2018 May 31;8(2):98-102. doi: 10.1159/000489771. eCollection 2018 May-Aug.
3
Bile cast nephropathy: A case report and review of the literature.胆汁管型肾病:一例病例报告及文献综述
World J Gastroenterol. 2016 Jul 21;22(27):6328-34. doi: 10.3748/wjg.v22.i27.6328.
4
Bile acid-induced cholemic nephropathy.胆汁酸诱导的胆血症性肾病。
Dig Dis. 2015;33(3):367-75. doi: 10.1159/000371689. Epub 2015 May 27.
5
Bile cast nephropathy is a common pathologic finding for kidney injury associated with severe liver dysfunction.胆汁淤积性肾病是严重肝功能障碍相关肾损伤的常见病理表现。
Kidney Int. 2013 Jul;84(1):192-7. doi: 10.1038/ki.2013.78. Epub 2013 Mar 13.
6
The pathology of jaundice-related renal insufficiency: cholemic nephrosis revisited.黄疸相关性肾功能不全的病理学:再探胆血症性肾病。
J Nephrol. 2006 Mar-Apr;19(2):229-33.