Becher H, Zähler K, Grube E, Schlief R, Lüderitz B
Medizinische Universitätsklinik, Innere Medizin, Kardiologie, Bonn.
Z Kardiol. 1988 Apr;77(4):227-32.
The echocardiographic contrast agent SHU 454 provides microbubbles of defined size (median 3 micron) in a solution of galactose and is available in different reproducible concentrations. In 22 patients with suspected tricuspid regurgitation, color flow mapping (CFM) Doppler echocardiography was performed before and after intravenous injection of 2-4 ml SHU 454. Without SHU 454 the diastolic blood flow was imaged on 13.6 +/- 7.5% (mean value + standard deviation) of the cross sectional area of the right ventricle (four-chamber view) in comparison to 39.0 +/- 15.0% with SHU 454 (p less than 0.001). For the right atrium, the area analyzed by CFM increased from 9.4 +/- 12.9% to 62.4 +/- 25.3% (p less than 0.001). The interindividual variability of measurements after injection of SHU 454 was 5.9 +/- 4.0% as compared to 10.7 +/- 6.9% without SHU 454 (p less than 0.05). These findings demonstrate that intravenous SHU 454 administration increases the detection of blood flow by CFM within the right heart.
超声心动造影剂SHU 454在半乳糖溶液中可提供大小确定（中位数为3微米）的微泡，且有不同的可重复浓度。在22例怀疑有三尖瓣反流的患者中，于静脉注射2 - 4 ml SHU 454前后进行了彩色血流图（CFM）多普勒超声心动图检查。未使用SHU 454时，右心室（四腔心切面）横截面积的13.6 +/- 7.5%（平均值 + 标准差）可成像舒张期血流，而使用SHU 454时为39.0 +/- 15.0%（p < 0.001）。对于右心房，CFM分析的面积从9.4 +/- 12.9%增加到62.4 +/- 25.3%（p < 0.001）。注射SHU 454后测量的个体间变异性为5.9 +/- 4.0%，而未使用SHU 454时为10.7 +/- 6.9%（p < 0.05）。这些发现表明，静脉注射SHU 454可增加CFM对右心内血流的检测。
